Animal Models of Chronic Migraine

Current Pain and Headache Reports
Tse-Ming Chou, Shih-Pin Chen

Abstract

Chronic migraine (CM) is a recalcitrant subtype of migraine which causes high degrees of disability, poor treatment responses, and frequent recurrences in sufferers. However, the pathophysiological mechanisms underlying the development and chronification of migraine attacks remain incompletely understood. A validated animal model could help to decipher the pathogenic mechanism of the disease, facilitating the development of possible therapeutic strategies for CM. In this review, we aimed to summarize current animal models of CM and discuss the validity of these models. Several methods have been available to induce recurrent headache-like behaviors or biochemical changes in rodents, including repeated dural application of inflammatory soup, chronic systemic infusion of nitroglycerin, repeated administration of acute migraine abortive treatment to simulate medication overuse headache, or genetic modification. These models exhibit some features that are believed to be associated with migraine; however, none of the model can recapitulate all the clinical phenotypes found in humans and each has its own weakness. The complex features of CM increase the difficulty of constructing a proper animal model. Nonetheless, currently available...Continue Reading

References

Jul 1, 1995·Nature Medicine·C WeillerH C Diener
Jun 5, 1997·European Journal of Pharmacology·D J WilliamsonR J Hargreaves
Jan 25, 2002·The New England Journal of Medicine·Peter J GoadsbyMichel D Ferrari
Feb 1, 2002·Nature Medicine·Hayrunnisa BolayMichael A Moskowitz
Mar 12, 2004·The New England Journal of Medicine·Jes OlesenUNKNOWN BIBN 4096 BS Clinical Proof of Concept Study Group
Sep 29, 2006·The European Journal of Neuroscience·A BergerotP J Goadsby
Oct 17, 2006·Headache·Sandra W Hamelsky, Richard B Lipton
Nov 3, 2006·Headache·David Dodick, Stephen Silberstein
Feb 16, 2007·Headache·Stephen D SilbersteinUNKNOWN Topiramate Chronic Migraine Study Group
Jul 20, 2007·Headache·Michael L Oshinsky, Sumittra Gomonchareonsiri
May 3, 2008·Current Opinion in Neurology·Katharina Eikermann-Haerter, Michael A Moskowitz
Nov 14, 2008·Headache·Peter J Goadsby, Richard Hargreaves
Apr 22, 2009·Current Opinion in Neurology·Marcelo E Bigal, Richard B Lipton
Jul 10, 2009·Current Pain and Headache Reports·Marcelo E Bigal, Richard B Lipton
Jul 21, 2009·Cephalalgia : an International Journal of Headache·J L NatoliR B Lipton
Jun 29, 2010·Annals of Neurology·Rami BursteinDavid Borsook
Aug 18, 2010·Cephalalgia : an International Journal of Headache·Weera SupornsilpchaiAnan Srikiatkhachorn
Nov 9, 2010·Current Pain and Headache Reports·Milena De FeliceFrank Porreca
Mar 5, 2011·British Journal of Pharmacology·Odd-Geir Berge
Sep 21, 2011·Nature Reviews. Neuroscience·Simon AkermanPeter J Goadsby
Oct 21, 2011·Cephalalgia : an International Journal of Headache·Inna SukhotinskyCenk Ayata
Feb 15, 2012·Nature Reviews. Neurology·Hans-Christoph DienerStephen D Silberstein
Apr 25, 2012·The Journal of Headache and Pain·Yong-Chen ChenShuu-Jiun Wang
Jan 1, 2011·Biology of Mood & Anxiety Disorders·Catherine Belzung, Maël Lemoine
Sep 12, 2012·Headache·Michael L OshinskyStephen D Silberstein
Oct 2, 2012·Annals of Indian Academy of Neurology·Peter J Goadsby
Oct 17, 2012·The Journal of Headache and Pain·Tzu-Hsien LaiShuu-Jiun Wang
Nov 30, 2012·Annual Review of Physiology·Daniela Pietrobon, Michael A Moskowitz
Dec 12, 2012·Cephalalgia : an International Journal of Headache·Richard J StarkShuu-Jiun Wang
May 15, 2013·Cephalalgia : an International Journal of Headache·Agustin Melo-Carrillo, Alberto Lopez-Avila

❮ Previous
Next ❯

Citations

May 18, 2019·The Journal of Headache and Pain·Willem Sebastiaan van Hoogstraten, Antoinette MaassenVanDenBrink
Mar 10, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Silvestre VicentVincenzo Cardinale
May 3, 2019·The Journal of Headache and Pain·Andrea M HarriottShih-Pin Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.