Animal models of dengue virus infection.

Viruses
Simona Zompi, Eva Harris

Abstract

The development of animal models of dengue virus (DENV) infection and disease has been challenging, as epidemic DENV does not naturally infect non-human species. Non-human primates (NHPs) can sustain viral replication in relevant cell types and develop a robust immune response, but they do not develop overt disease. In contrast, certain immunodeficient mouse models infected with mouse-adapted DENV strains show signs of severe disease similar to the 'vascular-leak' syndrome seen in severe dengue in humans. Humanized mouse models can sustain DENV replication and show some signs of disease, but further development is needed to validate the immune response. Classically, immunocompetent mice infected with DENV do not manifest disease or else develop paralysis when inoculated intracranially; however, a new model using high doses of DENV has recently been shown to develop hemorrhagic signs after infection. Overall, each model has its advantages and disadvantages and is differentially suited for studies of dengue pathogenesis and immunopathogenesis and/or pre-clinical testing of antiviral drugs and vaccines.

References

Oct 1, 1991·The American Journal of Tropical Medicine and Hygiene·W C HallC J Peters
Feb 1, 1990·The American Journal of Tropical Medicine and Hygiene·M G GuzmánL Morier
Mar 1, 1988·The American Journal of Tropical Medicine and Hygiene·S C KliksD S Burke
Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·J R BravoG P Kouri
Jan 1, 1974·Journal of Pharmaceutical Sciences·K A Pittman, G A Portmann
Jun 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·L H BarbosaC Buckler
Feb 1, 1980·Medical Microbiology and Immunology·N J MarchetteS B Halstead
Jan 1, 1983·The American Journal of Tropical Medicine and Hygiene·S B HalsteadN Sangkawibha
May 1, 1997·The American Journal of Tropical Medicine and Hygiene·S TheinJ Aaskov
Jul 1, 1997·Emerging Infectious Diseases·C G Moore, C J Mitchell
Aug 26, 1998·Journal of Neurovirology·C RamosE Llausás
Dec 16, 1998·Journal of Virology·A J Johnson, J T Roehrig
Jun 22, 2000·Virology·D E Mosier
Aug 22, 2000·The Journal of General Virology·K J HuangH Y Lei
Nov 21, 2000·American Journal of Epidemiology·M G GuzmánS B Halstead
Dec 29, 2000·Virus Genes·V Monroy, B H Ruiz
Feb 15, 2001·Journal of Medical Virology·C F LinY S Lin
Sep 11, 2001·Journal of Biomedical Science·H Y LeiC C Liu
Feb 19, 2003·FEMS Immunology and Medical Microbiology·Alena AtrasheuskayaGeorge Ignatyev
Jun 17, 2003·Nature Medicine·Juthathip MongkolsapayaGavin Screaton
Aug 26, 2003·Journal of Medical Virology·Kazunori OishiTsuyoshi Nagatake
Oct 15, 2003·Journal of Virology·Claire Y-H HuangRichard M Kinney
Jan 1, 1952·The American Journal of Tropical Medicine and Hygiene·A B SABIN
Apr 2, 2004·The Journal of Clinical Investigation·Alan L Rothman
Jul 24, 2004·The Journal of Infectious Diseases·Bridget A WillsMichael Levin
Feb 18, 2005·The Journal of Infectious Diseases·Tadeusz J KochelKevin L Russell
Jun 18, 2005·Virology·M V PaesO M Barth
Jun 25, 2005·Biologicals : Journal of the International Association of Biological Standardization·Thomas P MonathFarshad Guirakhoo

❮ Previous
Next ❯

Citations

Aug 22, 2013·Current Opinion in Infectious Diseases·Stephen J Thomas, Timothy P Endy
Sep 7, 2013·The Pediatric Infectious Disease Journal·Roland EllingMarkus Hufnagel
Jun 14, 2013·Journal of Biomedical Science·Shu-Wen WanYee-Shin Lin
Oct 12, 2012·PLoS Pathogens·Sebastian AguirreAna Fernandez-Sesma
Jun 20, 2014·PLoS Neglected Tropical Diseases·Ponpan MatangkasombutJuthathip Mongkolsapaya
Dec 24, 2013·Immunology Letters·Milene Silveira FerreiraPedro Fernando da Costa Vasconcelos
Apr 2, 2014·Parasites & Vectors·Lucky Ronald RuntuweneYuki Eshita
May 30, 2014·The Journal of Infectious Diseases·Christopher N MoresSilas A Davidson
May 30, 2014·The Journal of Infectious Diseases·M Cristina Cassetti, Stephen J Thomas
Dec 3, 2014·Antiviral Research·Darci R SmithBrian B Gowen
Aug 30, 2013·Expert Review of Vaccines·Monica A McArthurRobert Edelman
Nov 21, 2015·Vaccine·Jorge E OsorioDan T Stinchcomb
Oct 20, 2015·Vaccine·Vanessa V SarathyAlan D T Barrett
Apr 3, 2014·Annals of the New York Academy of Sciences·Stephen J Thomas
Nov 26, 2015·Nature Reviews. Immunology·Gavin ScreatonCatherine Roberts
Apr 2, 2016·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ya-Lang HuangShie-Liang Hsieh
Dec 3, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Wacharaporn TiyasatkulkovitJohn L VandeBerg
Jun 12, 2013·Current Opinion in Immunology·Michael A BrehmLeonard D Shultz
Aug 27, 2014·BioMed Research International·Carolina De La Guardia, Ricardo Lleonart
Mar 18, 2016·The Journal of Infectious Diseases·Jesse J WaggonerEva Harris
Sep 13, 2014·Cytokine & Growth Factor Reviews·Kevin Maringer, Ana Fernandez-Sesma
Apr 10, 2013·The American Journal of Pathology·Vivian Vasconcelos CostaMauro Martins Teixeira
Sep 30, 2015·BMC Microbiology·Veridiana Ester BarrosVictor Hugo Aquino
Oct 14, 2014·Frontiers in Immunology·Carlos A Sariol, Laura J White
Feb 11, 2015·Viral Immunology·Kleber Juvenal Silva FariasBenedito Antônio Lopes da Fonseca
May 1, 2016·Journal of Molecular Biology·David OlagnierJohn Hiscott
Aug 29, 2014·PLoS Neglected Tropical Diseases·James WhitehornCameron P Simmons
Jul 5, 2016·Frontiers in Immunology·Juan Carlos Yam-PucLeopoldo Flores-Romo
Jun 9, 2016·Journal of Neurovirology·Kim M LeeAndrew G MacLean
Jun 21, 2016·Expert Opinion on Investigational Drugs·Hemalatha BeesettiSathyamangalam Swaminathan

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
transgenic

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.