Animal models of intra-oral chemical carcinogenesis: a review
Early attempts to induce malignant oral tumours were largely unsuccessful, as the oral mucosa is considerably more resistant to the actions of chemical carcinogens than skin. The first consistent success came when strong carcinogens were applied to the hamster cheek pouch. This model remains the most popular for studies of intra-oral carcinogenesis and is discussed at length. The advantages and disadvantages are critically reviewed. The models of intra-oral carcinogenesis in extra-pouch sites in the hamster, mouse, rat and nonhuman primates are considered. The possible reasons for the relative resistance of oral mucosa to chemical carcinogens are discussed, particularly in relation to portals of entry and saliva. Finally, the relative merits of the more popular models of intra-oral carcinogenesis are briefly discussed.
Quantitative histological changes during early experimental carcinogenesis in the hamster cheek pouch
The effect of dinitrochlorobenzene (DNCB) on dimethylbenzathracene (DMBA) carcinogenesis on hamster buccal pouch
Basement membrane changes under neoplastic oral mucous membrane. Ultrastructural observations, review of the literature, and a unifying concept
Stereological quantification of histological parameters in turpentine-induced hyperplasia of hamster cheek pouch epithelium
Some effects of N-methylnitrosourea on the oral and odontogenic tissues of the Syrian golden hamster
The effect of turpentine on hamster cheek pouch mucosa: a model of epithelial hyperplasia and hyperkeratosis
Experimental production of lingual carcinomas in hamsters by local application of 9, 10-dimethyl-1, 2-benzanthracene
Experimental production of lingual carcinomas in hamsters: tumor characteristics and site of formation
The effect of dimethyl sulfoxide and topical triamcinolone on chemical carcinogenesis of hamster buccal pouch
The effect of oestrogen on 9,10-dimethyl-1,2-benzanthracene (DMBA)-induced cheek pouch carcinoma in castrated and non-castrated male Syrian golden hamsters
Ultrastructure and development of epithelial cell pseudopodia in chemically induced premalignant lesions of the hamster cheek pouch
Potentiating effect of vitamin A on 9-10 dimethyl 1-2 benzanthracene--carcinogenesis in the hamster cheek pouch
Ultrastructure of the dermal-epidermal junction in experimentally induced tumors and human oral lesions
Enhancement of chemical carcinogenesis in the hamster cheek pouch by prior topical application of vitamin A palmitate
Stereological analysis of histological parameters in experimental premalignant hamster cheek pouch epithelium
Comparison of experimental carcinogenesis in normal hamster cheek pouch and pouch treated previously by cryosurgery
Investigation of normal human saliva for possible anticarinogenic action and chemical carcinogenesis in mucous membranes
THE EFFECT OF A CARCINOGEN (DMBA) APPLIED TO THE HAMSTER'S BUCCAL POUCH IN COMBINATION WITH CROTON OIL
THE EFFECT OF LIVER IMBALANCE ON THE DEVELOPMENT OF ORAL TUMORS IN MICE FOLLOWING THE APPLICATION OF BENZPYRENE OR TOBACCO TAR
Effect of chronic mechanical irritation on chemically induced carcinogenesis in the hamster cheek pouch
The role of croton oil applications, associated with a single painting of a carcinogen, in tumour induction of the mouse's skin
Cell, tissue and organ culture as in vitro models to study the biology of squamous cell carcinomas of the head and neck
A modified method of carcinogenesis induction in the DMBA hamster cheek pouch model of squamous neoplasia
Mutagenicity of the oral carcinogen 4-nitroquinoline-1-oxide in cultured BigBlue rat tongue epithelial cells and fibroblasts
In vivo photo-detection of chemically induced premalignant lesions and squamous cell carcinoma of the rat palatal mucosa
Peptide analogues alter the progression of premalignant lesions, as measured by Photofrin fluorescence
Hemidesmosomal dimensions and frequency in experimental oral carcinogenesis: a stereological investigation
The effect of sodium lauryl sulphate on the expression of cytokeratin mRNA in hamster cheek pouch epithelium
Serum dipeptidyl peptidase (DPP) IV activity in hamster buccal pouch carcinogenesis with 9,10-dimethyl-1,2-benzanthracene
Animal models for the study of squamous cell carcinoma of the upper aerodigestive tract: a historical perspective with review of their utility and limitations. Part A. Chemically-induced de novo cancer, syngeneic animal models of HNSCC, animal models of transplanted xenogeneic human tumors
The effect of intraperitoneal N-methyl-N-nitrosourea on hamster palatal gingiva and intermolar mucosa
Histomorphometric analysis of epithelial changes in chemically induced oral mucosal carcinogenesis in rats
Structure of hamster palatal gingiva and intermolar mucosa after intraperitoneal dosing with N-methyl-N-nitrosourea: a scanning electron microscope study
Photofrin-mediated photodynamic therapy of chemically-induced premalignant lesions and squamous cell carcinoma of the palatal mucosa in rats
Green tea polyphenol protection against 4-nitroquinoline 1-oxide-induced bone marrow lipid peroxidation and genotoxicity in Wistar rats
Therapeutic efficacy of boron neutron capture therapy mediated by boron-rich liposomes for oral cancer in the hamster cheek pouch model
Localization and treatment of transformed tissues using the photodynamic sensitizer 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a
Regional lymph node metastasis created by partial excision of carcinomas induced in hamster cheek pouch with 9,10-dimethyl-1,2-benzanthracene
Modifying effects of dietary capsaicin and rotenone on 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis
Verrucous hyperplasia and verrucous carcinoma of the rat oral mucosa. Experimental oral carcinogenesis using 4-nitroquinoline 1-oxide
Preclinical models of head and neck squamous cell carcinoma for a basic understanding of cancer biology and its translation into efficient therapies
Development of a decellularized porcine bone graft by supercritical carbon dioxide extraction technology for bone regeneration.
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