Animal models of l-dopa-induced dyskinesia in Parkinson's disease

Movement Disorders : Official Journal of the Movement Disorder Society
M A Cenci, A R Crossman

Abstract

Understanding the biological mechanisms of l-dopa-induced motor complications is dependent on our ability to investigate these phenomena in animal models of Parkinson's disease. The most common motor complications consist in wearing-off fluctuations and abnormal involuntary movements appearing when plasma levels of l-dopa are high, commonly referred to as peak-dose l-dopa-induced dyskinesia. Parkinsonian models exhibiting these features have been well-characterized in both rodent and nonhuman primate species. The first animal models of peak-dose l-dopa-induced dyskinesia were produced in monkeys lesioned with N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and treated chronically with l-dopa to elicit choreic movements and dystonic postures. Seminal studies were performed in these models using both metabolic mapping and electrophysiological techniques, providing fundamental pathophysiological insights that have stood the test of time. A decade later, it was shown possible to reproduce peak-dose l-dopa-induced dyskinesia in rats and mice rendered parkinsonian with nigrostriatal 6-hydroxydopamine lesions. When treated with l-dopa, these animals exhibit abnormal involuntary movements having both hyperkinetic and dystonic compo...Continue Reading

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Citations

Apr 29, 2018·Journal of Neural Transmission·M Angela CenciPer Petersson
Oct 1, 2018·The European Journal of Neuroscience·Susan H Fox, Jonathan M Brotchie
Apr 20, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Kathy Steece-CollierFredric P Manfredsson
Dec 25, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·M Angela CenciRobert A Hauser
Sep 15, 2020·Experimental Neurobiology·Joshua A BlosserDaewoo Lee
Sep 19, 2018·Lab Animal·Douglas G HoweCynthia Smith
Mar 19, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Xi ChenWeidong Le
Jul 15, 2018·Journal of Neural Transmission·Angelo Antonini, Bianca Nitu
Nov 5, 2019·Frontiers in Neurology·Qiwei PengYan Xu
Nov 30, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Peter Jenner
Sep 10, 2020·Frontiers in Systems Neuroscience·Cristóbal Moënne-LoccozRómulo A Fuentes-Flores
Sep 29, 2020·British Journal of Pharmacology·Andrea Lopez-LopezAna Muñoz
May 7, 2021·Journal of Experimental Pharmacology·Andrea Fabbrini, Andrea Guerra
Jun 1, 2021·Frontiers in Aging Neuroscience·Haruo NishijimaMasahiko Tomiyama
Sep 4, 2021·World Neurosurgery·Osvaldo Vilela-FilhoCaroline B S S Milhomem

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