Animal models of lupus and lupus nephritis

Current Pharmaceutical Design
Yong DuChandra Mohan

Abstract

This article reviews the commonly used murine strains for studying lupus and lupus nephritis, including strains that develop lupus spontaneously, congenic strains, induced models of lupus, as well as genetically engineered mouse models of lupus bearing transgenes or knockouts. The review then summarizes the main cellular and molecular pathways that lead to the pathogenesis of this autoimmune disease, including autoantibodies. Finally, it concludes with therapeutic insights gained from using mouse models of lupus. To sum, much of what we have learned about lupus has arisen from studying mouse models of the disease, and the laboratory mouse continues to be one of the best tools for studying human SLE.

Citations

Mar 8, 2016·Nature Reviews. Nephrology·Stephen R HoldsworthA Richard Kitching
Aug 19, 2016·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Celine C BerthierAnne Davidson
Oct 11, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Francesco Paolo SchenaClaudia Curci
Nov 19, 2015·Frontiers in Immunology·Timothy A GottschalkMargaret L Hibbs
Dec 8, 2019·Clinical and Experimental Nephrology·Ling SunJie Wang
Oct 6, 2020·Frontiers in Medicine·Lindsey R TheutErika I Boesen
Jan 20, 2019·Nature Reviews. Rheumatology·Noa SchwartzChaim Putterman
Aug 29, 2020·Annual Review of Pharmacology and Toxicology·K Michael PollardDwight H Kono
May 1, 2021·International Journal of Molecular Sciences·Kyoko KawaharaYoshitaka Morita
Sep 18, 2021·Clinical Science·Erika I Boesen, Rahul M Kakalij

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