Animal models of obsessive-compulsive disorder: utility and limitations

Neuropsychiatric Disease and Treatment
Pino AlonsoJosé Manuel Menchón

Abstract

Obsessive-compulsive disorder (OCD) is a disabling and common neuropsychiatric condition of poorly known etiology. Many attempts have been made in the last few years to develop animal models of OCD with the aim of clarifying the genetic, neurochemical, and neuroanatomical basis of the disorder, as well as of developing novel pharmacological and neurosurgical treatments that may help to improve the prognosis of the illness. The latter goal is particularly important given that around 40% of patients with OCD do not respond to currently available therapies. This article summarizes strengths and limitations of the leading animal models of OCD including genetic, pharmacologically induced, behavioral manipulation-based, and neurodevelopmental models according to their face, construct, and predictive validity. On the basis of this evaluation, we discuss that currently labeled "animal models of OCD" should be regarded not as models of OCD but, rather, as animal models of different psychopathological processes, such as compulsivity, stereotypy, or perseverance, that are present not only in OCD but also in other psychiatric or neurological disorders. Animal models might constitute a challenging approach to study the neural and genetic me...Continue Reading

Citations

Apr 20, 2016·Frontiers in Neuroscience·Ester NespoliAndrea G Ludolph
Nov 12, 2016·Frontiers in Behavioral Neuroscience·Ales StuchlikJiri Horacek
Nov 5, 2019·The International Journal of Neuroscience·Yuhua ZhanXumei Wang
Mar 25, 2020·Neurotoxicity Research·Mahdi AbounooriMotahareh Rouhi Ardeshiri
Mar 4, 2020·Probiotics and Antimicrobial Proteins·Nafiseh Sadat SanikhaniSoudeh Ghafouri-Fard
Oct 27, 2018·Neuropharmacology·Ilya SukhanovAnton Yu Bespalov
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