Jan 1, 1996

Animal models of Parkinson's disease: an empirical comparison with the phenomenology of the disease in man

Journal of Neural Transmission
M Gerlach, P Riederer

Abstract

Animal models are an important aid in experimental medical science because they enable one to study the pathogenetic mechanisms and the therapeutic principles of treating the functional disturbances (symptoms) of human diseases. Once the causative mechanism is understood, animal models are also helpful in the development of therapeutic approaches exploiting this understanding. On the basis of experimental and clinical findings. Parkinson's disease (PD) became the first neurological disease to be treated palliatively by neurotransmitter replacement therapy. The pathological hallmark of PD is a specific degeneration of nigral and other pigmented brainstem nuclei, with a characteristic inclusion, the Lewy body, in remaining nerve cells. There is now a lot of evidence that degeneration of the dopaminergic nigral neurones and the resulting striatal dopamine-deficiency syndrome are responsible for its classic motor symptoms akinesia and bradykinesia. PD is one of many human diseases which do not appear to have spontaneously arisen in animals. The characteristic features of the disease can however be more or less faithfully imitated in animals through the administration of various neurotoxic agents and drugs disturbing the dopaminergi...Continue Reading

Mentioned in this Paper

Striatonigral Degeneration, Infantile (Disorder)
Pathogenic Aspects
Behavior, Animal
Alpha-Neurotoxins
Abnormal Degeneration
Pathogenesis
Entire Brainstem
Medicine
Hypokinesia
Neurosteroids

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