Animal models of Parkinson's disease: An updated overview

Revue neurologique
P Gubellini, P Kachidian

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder whose etiology, besides a minority of genetic cases, is still largely unknown. Animal models have contributed to elucidate PD etiology and pathogenesis, as well as its cellular and molecular mechanisms, leading to the general hypothesis that this neurological disorder is due to complex interactions between environmental and genetic factors. However, the full understanding of PD is still very far from being achieved, and new potential treatments need to be tested to further improve patients' quality of life and, possibly, slow down the neurodegenerative process. In this context, animal models of PD are required to address all these issues. "Classic" models are based on neurotoxins that selectively target catecholaminergic neurons (such as 6-hydroxydopamine, 1-methyl-1,2,3,6-tetrahydropiridine, agricultural pesticides, etc.), while more recent models employ genetic manipulations that either introduce mutations similar to those find in familial cases of PD (α-synuclein, DJ-1, PINK1, Parkin, etc.) or selectively disrupt nigrostriatal neurons (MitoPark, Pitx3, Nurr1, etc.). Each one of these models has its own advantages and limitations, thus some are better suited...Continue Reading

References

Sep 1, 1979·Drug and Alcohol Dependence·G C WagnerC R Schuster
Jan 1, 1975·Biochemical Pharmacology·C Sachs, G Jonsson
Dec 1, 1968·European Journal of Pharmacology·U Ungerstedt
Nov 11, 1998·Neuroscience and Biobehavioral Reviews·J Gauntlett-Gilbert, V J Brown
Mar 30, 1999·Brain Research·A I BrooksH J Federoff
May 21, 1999·The European Journal of Neuroscience·E BezardC E Gross
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·B J DayJ S Stamler
Oct 29, 2000·Trends in Neurosciences·P CalabresiG Bernardi
Jun 8, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·J E Ahlskog, M D Muenter
Jan 17, 2002·The Journal of Comparative Neurology·Tania VitalisOlivier Cases
Jul 3, 2002·Nature Reviews. Neuroscience·M Angela CenciTimothy Schallert
Apr 1, 2003·Nature Neuroscience·Barbara PicconiPaolo Calabresi
Apr 30, 2003·Journal of Neurochemistry·Mauro MaccarronePaolo Calabresi
Sep 16, 2003·Neuron·William Dauer, Serge Przedborski
Nov 1, 2003·Science·Ted M Dawson, Valina L Dawson
Apr 17, 2004·Science·Enza Maria ValenteNicholas W Wood
Feb 1, 2005·Lancet·William P GilksNicholas W Wood
Feb 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Francisco A Perez, Richard D Palmiter
Mar 9, 2005·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Peter Lindgren
Mar 24, 2005·Proceedings of the National Academy of Sciences of the United States of America·Raymond H KimTak W Mak
Mar 26, 2005·Brain Research. Molecular Brain Research·Richard Jay Smeyne, Vernice Jackson-Lewis
Aug 27, 2005·Brain : a Journal of Neurology·Wassilios MeissnerThomas Boraud
Dec 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Wanli W SmithChristopher A Ross
May 23, 2006·Lancet Neurology·Lonneke M L de Lau, Monique M B Breteler
Jul 4, 2006·Neurotoxicology·R J Dinis-OliveiraF Carvalho
Jan 18, 2007·Proceedings of the National Academy of Sciences of the United States of America·Mats I EkstrandNils-Göran Larsson
Apr 6, 2007·Annual Review of Biochemistry·Maria FalkenbergClaes M Gustafsson
Nov 28, 2007·The Journal of Biological Chemistry·Helena M Cochemé, Michael P Murphy
Nov 29, 2007·Journal of Neurochemistry·Imane NafiaLaurence Had-Aissouni
Mar 18, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·J Jankovic

❮ Previous
Next ❯

Citations

Mar 31, 2017·Journal of Neural Transmission·Javier BlesaJosé A Obeso
Dec 22, 2017·Cellular and Molecular Life Sciences : CMLS·Seyma BahdoudiDavid Vaudry
Sep 4, 2020·Experimental Biology and Medicine·Santosh R D'Mello, Mark C Kindy
May 22, 2016·Journal of Neurochemistry·Daniela Maria Vogt WeisenhornWolfgang Wurst
May 15, 2018·Parkinson's Disease·Raja MehannaJawad A Bajwa
Nov 2, 2017·Translational Neurodegeneration·Panchanan MaitiGary L Dunbar
Apr 25, 2020·Biomolecules·Farzad Salehpour, Michael R Hamblin
Jan 1, 2019·Journal of Chemical Neuroanatomy·Pollyana C LealJosé R Santos
Oct 27, 2018·Neuroscience and Biobehavioral Reviews·Fanny FaivreMichel Barrot
Jan 20, 2020·Neuroscience Research·Yuichi Takeuchi, Antal Berényi
Mar 3, 2020·Neuroscience Letters·Guobin SongCungen Ma
Jul 27, 2021·Frontiers in Aging Neuroscience·Upasana GangulySasanka Chakrabarti
Nov 11, 2019·Epilepsy & Behavior : E&B·Vinícius Rosa CotaMárcio Flávio Dutra Moraes
Apr 27, 2021··Wenjie You

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Related Papers

Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics
Weidong LeJoseph Jankovic
Human Molecular Genetics
Bobby Thomas, M Flint Beal
Journal of Biomedicine & Biotechnology
Javier BlesaSerge Przedborski
© 2021 Meta ULC. All rights reserved