Animal models of pituitary neoplasia

Molecular and Cellular Endocrinology
K E LinesR V Thakker

Abstract

Pituitary neoplasias can occur as part of a complex inherited disorder, or more commonly as sporadic (non-familial) disease. Studies of the molecular and genetic mechanisms causing such pituitary tumours have identified dysregulation of >35 genes, with many revealed by studies in mice, rats and zebrafish. Strategies used to generate these animal models have included gene knockout, gene knockin and transgenic over-expression, as well as chemical mutagenesis and drug induction. These animal models provide an important resource for investigation of tissue-specific tumourigenic mechanisms, and evaluations of novel therapies, illustrated by studies into multiple endocrine neoplasia type 1 (MEN1), a hereditary syndrome in which ∼ 30% of patients develop pituitary adenomas. This review describes animal models of pituitary neoplasia that have been generated, together with some recent advances in gene editing technologies, and an illustration of the use of the Men1 mouse as a pre clinical model for evaluating novel therapies.

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Citations

Oct 11, 2016·Molecular and Cellular Endocrinology·Gabriela CarrenoJuan Pedro Martinez-Barbera
Dec 20, 2017·Frontiers in Endocrinology·Hugo Vankelecom, Heleen Roose
Nov 27, 2018·The Journal of Endocrinology·Manuel D GaheteRaul M Luque
Mar 12, 2019·Endocrine-related Cancer·María Andrea CamillettiGraciela Diaz-Torga
Sep 7, 2019·Cancers·Daniela D'AngeloAlfredo Fusco
Dec 29, 2020·Frontiers in Endocrinology·Congxin DaiJun Kang

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Methods Mentioned

BETA
gene knockout
transgenic
gene trap
gene trapping
gene trap knockout
gene
gene knockdown

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