Animal models of rheumatoid arthritis-associated interstitial lung disease.

Immunity, Inflammation and Disease
Li XiongWan-Li Ma

Abstract

Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is an irreversible pathologic condition of unknown cause, commonly involving the joint and the lung with variable amounts of fibrotic change. In contrast to rheumatoid arthritis or other chronic interstitial lung diseases such as interstitial pulmonary fibrosis, there is so far no extensively accepted or implemented animal model for this disease. To provide guidance for those who are investigating the pathogenesis of RA-ILD with animal models. An analysis of papers from PubMed during 1978-2020. We outline the present status quo for animal models of RA-ILD about their modeling methods and pathogenesis, compare their pros and cons with respect to their ability to mimic the clinical and histological features of human disease and discuss their applicability for future research. There is no doubt that these animal models do provide valuable information relating to the pathogenesis of RA-ILD and the development of effective therapeutic drugs. Nevertheless, these animal models can not entirely recapitulate clinical pathology and have some limitations in experimental research application. Therefore, it should be emphasized that we should improve and explore animal model...Continue Reading

References

Feb 1, 1979·Seminars in Arthritis and Rheumatism·E R Hurd
Apr 13, 1978·The New England Journal of Medicine·C B CarringtonR G Gupta
Jan 1, 1984·Annual Review of Immunology·J M StuartA H Kang
May 1, 1998·American Journal of Respiratory and Critical Care Medicine·A L Katzenstein, J L Myers
Jan 13, 2000·The American Journal of Surgical Pathology·A L Katzenstein, J L Myers
Nov 8, 2001·Current Opinion in Rheumatology·S VeeraraghavanA U Wells
Aug 9, 2003·Springer Seminars in Immunopathology·Ping Li, Edward M Schwarz
Sep 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Satoshi KanazawaB Matija Peterlin
Jun 5, 2007·Nature Protocols·David D BrandEdward F Rosloniec
Apr 28, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jill A PooleDebra J Romberger
Aug 13, 2009·European Journal of Immunology·Darren L AsquithFoo Y Liew
Dec 10, 2009·The European Respiratory Journal·E J KimH R Collard
May 25, 2010·Arthritis and Rheumatism·Jason R KolfenbachV Michael Holers
Sep 21, 2010·American Journal of Respiratory and Critical Care Medicine·Amy L OlsonKevin K Brown
Dec 22, 2011·Experimental Lung Research·Rebecca C KeithDavid W H Riches
Mar 27, 2013·Arthritis and Rheumatism·Rebecca C KeithDavid W H Riches
May 16, 2013·American Journal of Respiratory Cell and Molecular Biology·Alexander V MisharinHarris Perlman
Sep 17, 2013·American Journal of Respiratory and Critical Care Medicine·William D TravisUNKNOWN ATS/ERS Committee on Idiopathic Interstitial Pneumonias
Nov 20, 2013·Current Opinion in Rheumatology·Samuel B BruscaJose U Scher
Mar 17, 2016·Trends in Molecular Medicine·Adam J ByrneClare M Lloyd
Oct 30, 2016·Lancet·Josef S SmolenIain B McInnes
Aug 30, 2017·American Journal of Respiratory Cell and Molecular Biology·Alexandra L McCubbreyWilliam J Janssen
Mar 16, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Elizabeth F RedenteDavid W H Riches
Apr 18, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jill A PooleTed R Mikuls
Aug 20, 2019·Journal of Cellular and Molecular Medicine·Yasuhiro TerasakiAkira Shimizu
Aug 29, 2019·Nature Reviews. Rheumatology·Dan WangRobert Vassallo

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Citations

Jun 26, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Suha Kadura, Ganesh Raghu

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