PMID: 11931722Apr 5, 2002Paper

Animal models of spontaneous plaque rupture: the holy grail of experimental atherosclerosis research

Current Atherosclerosis Reports
Michael E RosenfeldStephen M Schwartz

Abstract

Throughout the history of atherosclerosis research we have sought animal models of the disease process that exhibit high frequencies of the features that make human plaque a clinical risk: plaque rupture, mural thrombosis, and intra-plaque hemorrhage. This type of model is needed to determine the mechanisms by which plaques rupture and to design and test therapeutic interventions for stabilizing plaques. Studies of domestic and exotic animals have shown that most species will spontaneously develop fatty streaks and in some cases atheromatous lesions with sufficient time, but that rupture and thrombosis is exceedingly rare. Even with addition of fat and cholesterol to the diet, lesion development is accelerated but does not increase the frequency with which plaques rupture in most animal models. However, recently we have observed high frequencies of intra-plaque hemorrhage in the innominate/brachiocephalic arteries of older, chow-fed, hyperlipidemic, apolipoprotein E-deficient mice, and high frequencies of plaque rupture with mural thrombus in younger apolipoprotein E-deficient mice fed a high-fat diet. This suggests that plaque rupture and secondary thrombosis are frequent and reproducible occurrences at specific sites in apoli...Continue Reading

References

Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D GordonS M Schwartz
Sep 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M E Rosenfeld, R Ross
Feb 1, 1989·Experimental and Molecular Pathology·K W Weingand
Jan 1, 1987·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M E RosenfeldR Ross
Jul 3, 1969·Annals of the New York Academy of Sciences·D Kritchevsky
Sep 8, 1965·Annals of the New York Academy of Sciences·E G Dahme
Sep 8, 1965·Annals of the New York Academy of Sciences·T B ClarksonH B Lofland
Sep 8, 1965·Annals of the New York Academy of Sciences·G A Gresham, A N Howard
Sep 8, 1965·Annals of the New York Academy of Sciences·H C RowsellH G Downie
Jul 1, 1984·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·A Faggiotto, R Ross
May 3, 1984·The New England Journal of Medicine·M J Davies, A Thomas
Aug 1, 1995·Circulation·E FalkV Fuster
Jul 27, 1999·Circulation·S E EpsteinJ Zhu
Oct 26, 2000·Current Opinion in Lipidology·M SakaiS Horiuchi
Dec 16, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·M E RosenfeldS M Schwartz
Feb 13, 2001·Atherosclerosis·J L Johnson, C L Jackson
Jun 26, 2001·Diabetes·R G GerrityT Kimsey
Dec 12, 2001·Circulation Research·U Schönbeck, P Libby
Jan 5, 2002·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·R VirmaniA Farb

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Citations

Dec 5, 2009·Nature Reviews. Immunology·Ira Tabas
May 12, 2012·Mediators of Inflammation·Ting GuiYasuteru Muragaki
Mar 20, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Andrea R NawrockiPhilipp E Scherer
Sep 1, 2007·Journal of Cellular and Molecular Medicine·Ken A LindstedtPetri T Kovanen
Jun 23, 2015·Fundamental & Clinical Pharmacology·Raman P Priyadharsini
May 3, 2011·Cell·Kathryn J Moore, Ira Tabas
May 26, 2007·Circulation Research·Willa HsuehIra J Goldberg
Feb 22, 2017·Journal of the American Heart Association·Wen-Lin ChengHongliang Li
Apr 3, 2021·Frontiers in Cardiovascular Medicine·Xueyu WangJinwei Tian

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