Animal models of Vogt-Koyanagi-Harada disease (sympathetic ophthalmia)

Ophthalmic Research
Kunihiko Yamaki, Shigeaki Ohono

Abstract

We aimed to establish the animal model of Vogt-Koyanagi-Harada disease (VKH). Rats, Akita dogs and monkeys were immunized with the peptides derived from tyrosinase-related protein 1. Each experimental animal was examined clinically and histologically. The rats developed ocular and extraocular inflammation homologous to human VKH by immunization of tyrosinase-related protein 1. The Akita dogs also developed the autoimmune disease almost similar to the spontaneously emerging dog VKH equivalent to human VKH. The monkeys developed similar clinical findings as human VKH. These models may serve as human VKH models.

Citations

Feb 10, 2009·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·U Pleyer, M Dutescu
Jan 31, 2013·International Reviews of Immunology·John V ForresterLucia Kuffova
May 18, 2010·The Veterinary Clinics of North America. Small Animal Practice·Laurel J Gershwin
Jun 1, 2016·Survey of Ophthalmology·Ghazala A Datoo O'Keefe, Narsing A Rao
Apr 28, 2018·Journal of the American Veterinary Medical Association·Mitzi K ZarfossSara M Thomasy

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