PMID: 8948006Nov 1, 1996Paper

Animal models provide insight into psychosomatic factors in diabetes

Psychosomatic Medicine
R S Surwit, P G Williams

Abstract

To review the literature regarding the use of animal models in research addressing psychosomatic aspects of diabetes. We examine the key findings in animal model vs. human research in the area of stress and diabetes. Previous research has suggested that stress is a potential contributor to chronic hyperglycemia in diabetes. Stress affects metabolic activity via the stimulation of a variety of hormones that can result in elevated blood glucose levels. In patients with diabetes, due to a relative or absolute lack of insulin, stress-induced increases in glucose cannot be properly metabolized. Additionally, regulation of these stress hormones may be abnormal in diabetes. Human studies on the role of stress in the onset and course of type II diabetes are few and are limited by the constraints and logistics of examining life stress in humans. However, animal research allows for tight experimental control and the manipulation of factors that may contribute to the development and/or course of diabetes, such as stress, eating behavior, the nutrient content of food, and physical activity. Disease processes can be examined at a mechanistic level in animals which is typically limited in human research. There is a large body of animal work ...Continue Reading

References

Sep 1, 1975·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A Beloff-ChainK A Rookledge
Mar 11, 1976·The Journal of Clinical Investigation·R P RobertsonD Porte
Oct 1, 1992·Diabetes Care·R S SurwitM N Feinglos
Aug 1, 1991·Diabetes·J P Palmer, D K McCulloch
Jan 1, 1989·The Medical Clinics of North America·J RodinR Striegel-Moore
Jun 1, 1989·Diabetes·M A Banerji, H E Lebovitz
Nov 1, 1989·The Journal of Clinical Investigation·C BerneF Niklasson
Jun 1, 1985·Lancet·W FeldbergW A Stubbs
Mar 1, 1986·Psychosomatic Medicine·R S SurwitM N Feinglos
Sep 1, 1988·Diabetes·R S SurwitM N Feinglos
Jan 1, 1988·Diabetes Care·R S Surwit, M N Feinglos
Feb 1, 1988·Annals of Allergy·R J Becker
Apr 24, 1986·The New England Journal of Medicine·F W KemmerM Berger
Dec 1, 1986·Journal of Pediatric Psychology·A H BrandS B Johnson
Jun 1, 1985·Appetite·J M Slattery, R M Potter
Nov 1, 1973·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J Linde, T Deckert
Jan 1, 1984·Diabetes Care·D Giugliano
Jul 1, 1984·Diabetes·R S SurwitJ A McCubbin
May 1, 1982·Diabetes Care·R S SurwitM N Feinglos
Oct 1, 1982·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·P U DubucP L Willis
Aug 1, 1980·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R CapponiL Vargas
Feb 1, 1995·Diabetic Medicine : a Journal of the British Diabetic Association·J K Wales
May 1, 1995·Metabolism: Clinical and Experimental·R S SurwitM Rebuffé-Scrive
Jan 1, 1995·Life Sciences·C M KuhnM N Feinglos
Jul 1, 1994·The Journal of Clinical Investigation·M F SeldinR S Surwit
Jul 1, 1993·Psychosomatic Medicine·R S Surwit, M S Schneider
Feb 16, 1952·Journal of the American Medical Association·L E HINKLE, S WOLF

❮ Previous
Next ❯

Citations

Mar 29, 2002·American Journal of Public Health·Sandra A Black
Feb 18, 2003·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·O M WolkowitzV I Reus
Jun 7, 2005·Diabetes Research and Clinical Practice·Jessica M RobbinsStanislav V Kasl
Oct 16, 2003·Biochimica Et Biophysica Acta·Fernanda M FerreiraMaria S Santos
Nov 28, 2019·Journal of Advanced Nursing·Raquel Yvonne Reynolds
Mar 20, 2010·Obesity·Richard S SurwitAnastasia Georgiades
Jun 29, 2006·ILAR Journal·Janice E WagnerJay R Kaplan
Jun 18, 2002·Ageing Research Reviews·Kurt Heininger
Dec 14, 2002·Journal of Psychosomatic Research·Allison B GrigsbyPatrick J Lustman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Psychosomatic Medicine
G M PERRIN, I R PIERCE
Zeitschrift für Psychosomatische Medizin und Psychoanalyse
W Kämmerer, A Reindell
© 2021 Meta ULC. All rights reserved