Animal models to investigate pathomechanisms and evaluate novel treatments for autoimmune bullous dermatoses

Current Pharmaceutical Design
Hiroaki IwataRalf J Ludwig

Abstract

Autoimmune bullous dermatoses (AIBD), such as pemphigus, bullous pemphigoid or epidermolysis bullosa acquisita, are prototypical organ-specific autoimmune diseases. Clinically they are characterized by widespread mucocutaneous blistering, which is often difficult to treat. Patients with AIBD suffer from a significant morbidity and an increased mortality. In AIBD blistering is caused by autoantibodies targeting structural proteins of the skin. During the past decades animal models of AIBD have been developed. These animal models have greatly contributed to our current understanding of AIBD pathogenesis. Most of these insights, however, still await their translation into clinical use. Recently, AIBD animal models have been used to test the efficacy of known and novel drugs. Hence, these models are now not only employed to unravel the pathogenesis of AIBD, but also to assess therapeutic approaches to address the so far unmet high medical need for new treatments. We here review animal model of AIBD: In addition to spontaneously arising AIBD in animals, AIBD can be induced, mostly in mice, by (i) transfer of (auto)-antibodies, (ii) transfer of (auto)-antigen specific lymphocytes, (iii) immunization or (iv) by genetic modifications l...Continue Reading

Citations

Oct 25, 2016·The Journal of Investigative Dermatology·Hiroshi KogaRalf J Ludwig
Jan 15, 2016·The Journal of Investigative Dermatology·Michael KasperkiewiczRalf J Ludwig
Feb 12, 2019·Frontiers in Immunology·Mayumi Kamaguchi, Hiroaki Iwata
Mar 16, 2018·Frontiers in Immunology·Xinhua YuFrank Petersen
Aug 10, 2018·Laboratory Investigation; a Journal of Technical Methods and Pathology·Mayumi KamaguchiHiroshi Shimizu

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