Animal testing and its alternatives - the most important omics is economics

ALTEX
Lucy MeigsThomas Hartung

Abstract

For a long time, the discussion about animal testing vs its alternatives centered on animal welfare. This was a static warfare, or at least a gridlock, where life scientists had to take a position and make their value choices and hardly anyone changed sides. Technical advances have changed the frontline somewhat, with in vitro and in silico methods gaining more ground. Only more recently has the economic view begun to have an impact: Many animal tests are simply too costly, take too long, and give misleading results. As an extension and update to previous articles in this series written a decade ago, we reanalyze the economic landscape of especially regulatory use of animal testing and this time also consider respective alternative tests. Despite some ambiguity and data gaps, which we have filled with crude estimates, a picture emerges of globally regulated industries that are subject to stark geographic and sectorial differences in regulation, which determine their corresponding animal use. Both animal testing and its alternatives are industries in their own right, offering remarkable business opportunities for biotech and IT companies as well as contract research organizations. In light of recent revelations as to the reprodu...Continue Reading

Citations

Jul 20, 2019·Alternatives to Laboratory Animals : ATLA·Renato Ivan de Ávila, Marize Campos Valadares
Aug 12, 2020·Laboratory Investigation; a Journal of Technical Methods and Pathology·Heather L CiallellaHao Zhu
Sep 16, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Artur Christian Garcia da SilvaMarize Campos Valadares
Jul 7, 2020·EFSA Journal·Anna LanzoniMaged Younes
Jul 17, 2020·Chemical Research in Toxicology·Joyce V B BorbaCarolina Horta Andrade
Feb 15, 2021·Trends in Biotechnology·Sasan Jalili-FiroozinezhadJoaquim M S Cabral
Oct 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Abdul-Hamid EmwasMariusz Jaremko
Feb 16, 2021·Expert Opinion on Drug Metabolism & Toxicology·Emma E J Kasteel, Remco H S Westerink
Dec 24, 2020·Small·Ellen FritscheKatharina Koch
May 26, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Arianna FediSilvia Scaglione
Jul 1, 2021·Trends in Pharmacological Sciences·Terry ChingYu Shrike Zhang
Oct 6, 2021·Pharmacology Research & Perspectives·Susana B Gorzalczany, Angeles G Rodriguez Basso

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