Animal use in the chemical and product manufacturing sectors - can the downtrend continue?

Alternatives to Laboratory Animals : ATLA
Rodger Curren

Abstract

During the 1990s and early 2000s, a number of manufacturing companies in the cosmetic, personal care and household product industries were able to substantially reduce their use of animals for testing (or to not use animals in the first place). These reductions were almost always the result of significant financial contributions to either direct, in-house alternatives research, or to support personnel whose duties were to understand and apply the current state-of-the-art for in vitro testing. They occurred almost exclusively in non-regulatory areas, and primarily involved acute topical toxicities. Over the last few years, the reduction in animal use has been much less dramatic, because some companies are still reluctant to change from the traditional animal studies, because systemic, repeat-dose toxicity is more difficult to model in vitro, and because many products still require animal testing for regulatory approval. Encouragingly, we are now observing an increased acceptance of non-animal methods by regulatory agencies. This is due to mounting scientific evidence from larger databases, agreement by companies to share data and testing strategies with regulatory agencies, and a focus on smaller domains of applicability. These ...Continue Reading

References

Jun 20, 2006·Mutation Research·Rodger D CurrenMarilyn J Aardema
Aug 3, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·K KejlováM Liebsch
Jun 6, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Laurie ScottValérie Zuang
Nov 13, 2009·ALTEX·Thomas Hartung, Sebastian Hoffmann

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