Animal versus plant protein and adult bone health: A systematic review and meta-analysis from the National Osteoporosis Foundation

PloS One
Marissa M Shams-WhiteConnie M Weaver

Abstract

Protein may have both beneficial and detrimental effects on bone health depending on a variety of factors, including protein source. The aim was to conduct a systematic review and meta-analysis evaluating the effects of animal versus plant protein intake on bone mineral density (BMD), bone mineral content (BMC) and select bone biomarkers in healthy adults. Searches across five databases were conducted through 10/31/16 for randomized controlled trials (RCTs) and prospective cohort studies in healthy adults that examined the effects of animal versus plant protein intake on 1) total body (TB), total hip (TH), lumbar spine (LS) or femoral neck (FN) BMD or TB BMC for at least one year, or 2) select bone formation and resorption biomarkers for at least six months. Strength of evidence (SOE) was assessed and random effect meta-analyses were performed. Seven RCTs examining animal vs. isoflavone-rich soy (Soy+) protein intake in 633 healthy peri-menopausal (n = 1) and post-menopausal (n = 6) women were included. Overall risk of bias was medium. Limited SOE suggests no significant difference between Soy+ vs. animal protein on LS, TH, FN and TB BMD, TB BMC, and bone turnover markers BSAP and NTX. Meta-analysis results showed on average, t...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Mar 1, 1996·American Journal of Epidemiology·D FeskanichG A Colditz
Jan 30, 1999·The American Journal of Clinical Nutrition·R G MungerB C Chiu
Sep 1, 2000·The American Journal of Clinical Nutrition·D L AlekelT Toda
Dec 29, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M T HannanD P Kiel
Mar 27, 2002·American Journal of Epidemiology·Joanne H E PromislowElizabeth Barrett-Connor
Mar 28, 2002·The American Journal of Clinical Nutrition·Bess Dawson-Hughes, Susan S Harris
Mar 4, 2003·The Journal of Nutrition·Bess Dawson-Hughes
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Sep 23, 2003·Menopause : the Journal of the North American Menopause Society·Michael J MurrayMarc A Fritz
Jul 9, 2004·JAMA : the Journal of the American Medical Association·Sanne Kreijkamp-KaspersYvonne T van der Schouw
Nov 18, 2004·The Journal of Clinical Endocrinology and Metabolism·Jane E KerstetterKarl L Insogna
Sep 15, 2005·Archives of Internal Medicine·Xianglan ZhangWei Zheng
Jan 11, 2007·Menopause : the Journal of the North American Menopause Society·Ellen M EvansDennis T Villareal
Jan 26, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B Dawson-HughesG E Dallal
Mar 31, 2007·International Journal of Medical Sciences·Manuel T Velasquez, Sam J Bhathena
May 13, 2008·The American Journal of Clinical Nutrition·Robert P Heaney, Donald K Layman
Jul 31, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Patricia Dargent-MolinaMarie-Christine Boutron-Ruault
Mar 13, 2009·The American Journal of Clinical Nutrition·Janet R HuntZ K Fariba Roughead
May 29, 2009·The American Journal of Clinical Nutrition·Anne M KennyJane E Kerstetter
Jul 28, 2009·Journal of Clinical Epidemiology·David MoherUNKNOWN PRISMA Group
Sep 18, 2009·The American Journal of Clinical Nutrition·William W WongE O'Brian Smith
Nov 13, 2009·The American Journal of Clinical Nutrition·D Lee AlekelC Theodore Peterson
Jul 28, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Shivani SahniMarian T Hannan
Mar 3, 2011·The Journal of Nutrition, Health & Aging·E S ZoltickM T Hannan
Sep 14, 2011·International Journal of Cell Biology·Stephen P HigginsPaul J Higgins
Aug 15, 2012·Journal of Nutrition in Gerontology and Geriatrics·Connie M WeaverMartin J Ronis
Feb 27, 2013·Advances in Chronic Kidney Disease·Julia J Scialla, Cheryl A M Anderson
Apr 29, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Nicole C WrightBess Dawson-Hughes
Sep 4, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Amy JenningsAedín Cassidy
Sep 29, 2015·The Journal of Nutrition, Health & Aging·L LangsetmoUNKNOWN CaMos Research Group
May 28, 2016·Archives of Osteoporosis·Taylor C WallaceAndrea J Singer
Jun 8, 2017·Nutrients·Renata Alves CarnaubaGilberti Helena Hübscher

❮ Previous
Next ❯

Citations

Aug 11, 2018·The Proceedings of the Nutrition Society·Eimear Dolan, Craig Sale
Jan 25, 2019·International Journal of Sport Nutrition and Exercise Metabolism·Graeme L CloseStephane Bermon
Mar 28, 2020·Nutrients·Changwei CaoChangrong Ge
Jul 16, 2020·Advances in Nutrition·Stuart M PhillipsDonald K Layman
Jul 4, 2020·Current Opinion in Endocrinology, Diabetes, and Obesity·Emory Hsu
Jul 9, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M-K Choi, Y-J Bae
Mar 25, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A L DarlingS A Lanham-New
Nov 28, 2020·The Journal of Nutrition·Connie M Weaver
Nov 6, 2020·Current Opinion in Clinical Nutrition and Metabolic Care·Ben KirkGustavo Duque
Jan 10, 2021·Current Osteoporosis Reports·Laila S Tabatabai, Deborah E Sellmeyer
Apr 24, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Z-M LiuY-M Chen
Jun 3, 2021·Foods·Maite M AldayaMaría José Beriain
Oct 14, 2021·Critical Reviews in Food Science and Nutrition·Weili FengAnqi Lu
Mar 8, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ashley A WeaverDenise K Houston

❮ Previous
Next ❯

Software Mentioned

Scopus
Cochrane ROB
Stata SE
PROSPERO
Ovid

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.