PMID: 6026676Jul 7, 1967Paper

Animals at very high pressures of helium and neon

Science
K W MillerE B Smith

Abstract

At pressures up to 125 atmospheres, helium failed to anesthetize mice; at slightly higher pressures (135 to 145 atmospheres) it proved lethal. With Italian newts (Triturus italicus), whose sensitivity to anesthesia by nitrogen is similar to that of mice, responsiveness was lost at pressures between 165 and 245 atmospheres, whether the pressure was achieved with helium or neon, or hydrostatically. It was concluded that the anesthetic pressures of helium and neon, for mice and newts, are higher than the tolerable mechanical pressures.

References

Sep 1, 1954·The American Journal of Physiology·F G CARPENTER
Jul 7, 1961·Science·L PAULING
Sep 15, 1961·Proceedings of the National Academy of Sciences of the United States of America·S L MILLER
Jun 5, 1964·Science·J H MEMBERY, E A LINK

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Citations

Nov 1, 1980·Neuropharmacology·D D KoblinW D Paton
Aug 7, 2013·Medical Gas Research·Carlos J Berganza, John H Zhang
Sep 15, 2010·Critical Care : the Official Journal of the Critical Care Forum·Robert Dickinson, Nicholas P Franks
Nov 1, 1970·The Journal of Surgical Research·P S Malchesky, Y Nosé
Oct 3, 1970·Nature·S M Johnson, K W Miller
Jun 11, 1971·Nature·M J LeverE B Smith
Jan 7, 1984·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R A SmithK W Miller
Nov 10, 1967·Science·J A KylstraH A Saltzman

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