PMID: 1214281Dec 4, 1975Paper

Anion permeation in the proximal tubule of Necturus kidney: the shunt pathway

The Journal of Membrane Biology
T Anagnostopoulos

Abstract

The effect of foreign anions on transepithelial potential difference and transepithelial input conductance was studied in the isolated perfused Necturus kidney. Two microelectrodes (recording and current-injecting) were inserted into the lumen of single proximal tubules and the peritubular perfusate was shifted reversibly for 30-60 sec from a physiologic Ringer's solution to a test solution in which chloride was replaced isosmotically by a foreign anion. The permeability sequence, obtained by potential measurements, was: lactate less than glutamate less than gluconate less than pyruvate less than benzene sulfonate less than or equal to acetate less than or equal to F less than propionate less than BrO3 less than formate less than ClO3 less than Cl than ClO4 less than I less than or equal to Br less than NO3 less than SCN. Transepithelial conductance decreased when the tissue was perfused with anions less permeable than chloride but the conductance sequence was different from the permeability sequence. Such discrepancies were more pronounced during perfusion with hyperpolarizing anions; ClO4 and I- (both more permeable than chloride) produced an important decrease in transepithelial conductance, followed by incomplete reversibil...Continue Reading

References

May 12, 1976·Pflügers Archiv : European journal of physiology·A Edelman, T Anagnostopoulos
Jan 1, 1974·Pflügers Archiv : European journal of physiology·E Frömter, K Gessner
Sep 1, 1973·The Journal of Physiology·T Anagnostopoulos
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Citations

Sep 1, 1979·Pflügers Archiv : European journal of physiology·T Anagnostopoulos, G Planelles
Jan 1, 1983·Pflügers Archiv : European journal of physiology·G PlanellesT Anagnostopoulos
May 12, 1976·Pflügers Archiv : European journal of physiology·A Edelman, T Anagnostopoulos
Jan 18, 1978·The Journal of Membrane Biology·K R Spring, G Kimura
Jan 1, 1987·The Journal of Membrane Biology·P S Steels, E L Boulpaep
Jul 20, 2004·Pflügers Archiv : European journal of physiology·Gabrielle Planelles
May 1, 1980·The Journal of General Physiology·T AnagnostopoulosA Edelman
Feb 1, 1976·Kidney International·E E Windhager, G Giebisch
Dec 4, 1978·Biochimica Et Biophysica Acta·A EdelmanT Anagnostopoulos
Nov 5, 2003·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·Jorge Fischbarg
Jan 1, 1981·The Journal of Membrane Biology·A EdelmanT Anagnostopoulos

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