Jan 1, 1976

Anion transport and membrane morphology

The Journal of Membrane Biology
R B Gunn, R G Kirk

Abstract

Freeze-fracture electronmicroscopy has been used to examine the membrane ultrastructure of human red blood cells in the presence of inhibitors of chloride exchange. The extent of inhibition was correlated with a decrease of intramembrane particle density on the B-fracture face. Dimethylsulfoxide (DMSO) and glycerol, which markedly and reversibly reduced the intramembrane particle density, were shown to drastically and reversibly inhibit chloride self-exchange. DMSO was shown to be a noncompetitive inhibitor of chloride flux.

  • References14
  • Citations6

Mentioned in this Paper

Chloride Ion Level
Butanols
Glycerin
Dimethyl Sulfoxide
Science of Morphology
Red blood cells, blood product
Potassium
Sodium
Metabolic Inhibition
Cresols

About this Paper

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