Anionic carbonato and oxalato cobalt(III) nitrogen mustard complexes

Dalton Transactions : an International Journal of Inorganic Chemistry
Peter R CraigDavid C Ware

Abstract

Synthetic approaches to cobalt(III) complexes [Co(L)(L')2] containing the bidentate dialkylating nitrogen mustard N,N-bis(2-chloroethyl)-1,2-ethanediamine (L = dce) together with anionic ancilliary ligands (L') which are either carbonato (CO3(2-)), oxalato (ox2-), bis(2-hydroxyethyl)dithiocarbamato (bhedtc-), 2-pyridine carboxylato (pico-) or 2-pyrazine carboxylato (pyzc-) were investigated. Synthetic routes were developed using the related amines N,N-diethyl-1,2-ethanediamine (dee) and 1,2-ethanediamine (en). The complexes [Co(CO3)2(L)]- (L = dee 1, dce 2), [Co(ox)2(L)]- (L = dee 3, dce 4), [Co(bhedtc)2(dee)]+ 5, [Co(bhedtc)2(en)]+ 6, mer-[Co(pico)3], mer-[Co(pyzc)]3 7 and [Co(pico)2(dee)]+ 8 were prepared and were characterised by IR, UV-Vis, 1H and 13C[1H] NMR spectroscopy, mass spectrometry and cyclic voltammetry. [Co(bhedtc)2(en)]BPh4 6b and trans(O)-[Co(pico)2(dee)]ClO4 8 were characterised by X-ray crystallography. In vitro biological tests were carried out on complexes 1-4 in order to assess the degree to which coordination of the mustard to cobalt attenuated its cytotoxicity, and the differential toxicity in air vs. nitrogen.

Citations

Jun 11, 2011·Chemical Communications : Chem Comm·Alan M DownwardRichard M Hartshorn
Jan 27, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Subhendu KarmakarArindam Mukherjee
May 28, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Subhendu KarmakarArindam Mukherjee
Oct 8, 2013·Journal of the American Chemical Society·Qi-Qiang WangKristin Bowman-James
Jul 8, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Catherine R Munteanu, Kogularamanan Suntharalingam
Jan 11, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Subhendu KarmakarArindam Mukherjee
Dec 1, 2018·Chemical Society Reviews·Martin R Gill, Katherine A Vallis
Sep 11, 2007·Dalton Transactions : an International Journal of Inorganic Chemistry·Matthew D HallTrevor W Hambley
Jul 22, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Isabela Cristina Aguiar de SouzaMauricio Lanznaster
Dec 14, 2012·Journal of the Royal Society, Interface·Guillermo J AmadorDavid L Hu
Dec 24, 2018·Chemical Society Reviews·Amit SharmaJong Seung Kim
Aug 14, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Paul D BonnitchaTrevor W Hambley
Jan 9, 2020·Journal of Inorganic Biochemistry·Subhendu KarmakarArindam Mukherjee
Nov 24, 2020·Inorganic Chemistry·Marlene MathuberChristian R Kowol
May 29, 2021·Inorganic Chemistry Frontiers·Marlene MathuberChristian R Kowol
Aug 12, 2009·Journal of Inorganic Biochemistry·Elizabeth Teixeira SouzaMarciela Scarpellini

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