Anisakis simplex s.l.: Larvicidal activity of various monoterpenic derivatives of natural origin against L3 larvae in vitro and in vivo

Experimental Parasitology
M C NavarroA Valero

Abstract

This paper describes the activity against Anisakis simplex s.l. L(3) larvae of six monoterpenic derivatives obtained from different essential oils, (alpha-pinene, beta-pinene, ocimene, myrcene, geranyl acetate, and cineole). In in vitro assays, alpha-pinene, ocimene and cineole showed high activity at a concentration of 125 microg/mL (48h) but only alpha-pinene and ocimene were active at 62.5 microg/mL. In in vivo assays, L(3) larvae and study compounds were simultaneously administered per os to Wistar rats. The most active compound was alpha-pinene, finding lesions in only 20% of treated rats versus 98% of controls. Further in vivo studies are required to investigate whether addition of these compounds to food could have a prophylactic effect, reducing the pathogenicity of A. simplex s.l. L(3) in humans, and to explore any possible synergy among compounds.

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Citations

Apr 12, 2014·Experimental Parasitology·F GiarratanaA Panebianco
Jun 27, 2014·BioMed Research International·Carlota Gómez-RincónVíctor López
Mar 9, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Maria del Carmen RomeroMaría Concepción Navarro-Moll
Oct 12, 2010·Experimental Parasitology·Ma Concepción Navarro-MollAdela Valero
Sep 5, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Sebastião A MendanhaAntonio Alonso
Jan 30, 2014·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Iara Tersia Freitas MacedoClaudia Maria Leal Bevilaqua
Sep 30, 2009·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L A BarrosJ Bonaldo
Dec 13, 2016·Pharmaceutical Biology·Magdalena Gómez-Mateos PérezAdela Valero López
Sep 5, 2019·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Natália Berne PintoFábio Pereira Leivas Leite
Feb 29, 2020·Digestive Diseases and Sciences·Magdalena Gómez-MateosAdela Valero
Sep 1, 2015·Asian Pacific Journal of Tropical Medicine·A ValeroM C Navarro
Jun 26, 2017·Asian Pacific Journal of Tropical Medicine·Filippo GiarratanaAntonio Panebianco
Dec 11, 2017·Chemistry & Biodiversity·Ana María García-BoresJosé Guillermo Avila-Acevedo
Jul 11, 2018·Antimicrobial Agents and Chemotherapy·Ivona MladineoConcetta Messina
Jul 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wanda MączkaMałgorzata Grabarczyk

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