Anisakis simplex: stage-specific antigens recognized by mice

Journal of Helminthology
R IglesiasM L Sanmartín

Abstract

To investigate antigenic differences between the developmental stages of Anisakis simplex, somatic, excretion-secretion and detergent-solubilized surface antigen preparations of third- and fourth-stage A. simplex larvae, and a somatic antigen preparation of adults, were characterized by SDS-PAGE and immunoblotting using mouse immune serum containing antibodies against the two larval stages. Excretion-secretion and surface antigen preparations from third-stage larvae behaved very differently from those of fourth-stage larvae, in both SDS-PAGE and immunoblotting; this suggests that certain excretion-secretion and surface antigens are highly stage-specific. By contrast, somatic components of third- and fourth-stage larvae were found to have very similar banding patterns, suggesting conservation of these components during the development of the parasite in mice. The SDS-PAGE and immunoblotting results for adult somatic components seem to support this hypothesis.

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Citations

Apr 11, 2008·Clinical Microbiology Reviews·M Teresa Audicana, Malcolm W Kennedy
Jul 29, 2005·Medical Microbiology and Immunology·Esperanza RodríguezTeresa Gárate
Dec 13, 2003·Allergologia et immunopathologia·A VallsM Martín Esteban
Dec 16, 2006·The Korean Journal of Parasitology·Sung-Weon Cho, Haneul Nari Lee

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