Anisamide-targeted stealth liposomes: a potent carrier for targeting doxorubicin to human prostate cancer cells

International Journal of Cancer. Journal International Du Cancer
Rajkumar BanerjeeLeaf Huang

Abstract

Certain human malignancies including prostate cancer overexpress sigma receptor, a membrane bound protein that binds haloperidol and various other neuroleptics with high affinity. An anisamide derivatized ligand possesses high affinity for sigma receptors and we hypothesized that its incorporation into the liposomes encapsulating doxorubicin (DOX) can specifically target and deliver the drug to prostate cancer cells that overexpress sigma receptors. A polyethylene glycol phospholipid was derivatized with an anisamide ligand, which was then incorporated into the DOX-loaded liposome. The resulting anisamide-conjugated liposomal DOX showed significantly higher toxicity to DU-145 cells than non-targeted liposomal DOX, the IC50 being 1.8 microM and 14 microM respectively. The cytotoxicity of the targeted liposomal DOX, however, was significantly blocked by haloperidol, suggesting that the enhanced cytotoxicity was specifically mediated by the sigma receptors. Fluorescence imaging studies after intravenous (i.v.) administration showed that incorporation of anisamide into liposomes significantly improved their accumulation into the tumor. A weekly injection of the targeted liposomal DOX for 4 weeks at a dose of 7.5 mg/kg led to a sign...Continue Reading

Citations

Jun 17, 2010·Journal of the American Chemical Society·Osamu NakagawaRudolph L Juliano
Jan 1, 2009·Molecular Pharmaceutics·Kun Gao, Leaf Huang
Apr 5, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Shyh-Dar LiLeaf Huang
Dec 22, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yang YangLeaf Huang
Dec 12, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yuhua WangLeaf Huang
Jun 19, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yuan ZhangLeaf Huang
Jun 19, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yuhua WangLeaf Huang
Oct 10, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Shyh-Dar LiLeaf Huang
Jul 31, 2009·Chemical Communications : Chem Comm·Santanu Bhattacharya, Avinash Bajaj
Jul 12, 2012·The Journal of Biological Chemistry·Haydee LaraPilar Blancafort
Aug 20, 2010·Nucleic Acids Research·John A BaumanRyszard Kole
Feb 26, 2013·Nanoscale Research Letters·Abolfazl AkbarzadehKazem Nejati-Koshki
Jul 2, 2011·Nanomedicine·Jesse V JokerstSanjiv S Gambhir
Mar 28, 2013·Journal of Drug Delivery·Federico Perche, Vladimir P Torchilin
Mar 19, 2013·Trends in Molecular Medicine·Jianfeng GuoCaitriona M O'Driscoll
Jan 18, 2013·Therapeutic Delivery·Srinivas Ramishetti, Leaf Huang
Nov 13, 2013·Cancer Treatment Reviews·Jan KroonGabri van der Pluijm
Apr 12, 2014·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ankitkumar S JainMangal S Nagarsenker
Mar 19, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jing ZhangLeaf Huang
Aug 16, 2014·BioMed Research International·Patricia Marqués-Gallego, Anton I P M de Kroon
Jan 26, 2010·Expert Opinion on Drug Delivery·Thomas Kaasgaard, Thomas L Andresen
Jan 18, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Athanasia DasargyriJean-Christophe Leroux
Sep 17, 2015·Molecular Therapy : the Journal of the American Society of Gene Therapy·Rumwald Leo G LecarosYih-Chih Hsu
Jan 2, 2016·International Journal of Pharmaceutics·Kathleen A FitzgeraldCaitriona M O'Driscoll
Dec 12, 2012·Nanomedicine : Nanotechnology, Biology, and Medicine·Yuen Yi C TamPieter R Cullis
Oct 9, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Neeraj K GargRajeev K Tyagi
Aug 29, 2012·European Journal of Medicinal Chemistry·Prathap Reddy MuktapuramSurendar Reddy Bathula
Nov 8, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jun LiLeaf Huang
Feb 19, 2011·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Alina ShapiraYehuda G Assaraf
Apr 13, 2010·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M Wang, M Thanou
Nov 19, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jun LiLeaf Huang
Mar 5, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yuanke LiJing Yao
Mar 31, 2009·Advanced Drug Delivery Reviews·Yu-Cheng TsengLeaf Huang
Aug 6, 2010·The Journal of Investigative Dermatology·Yunching ChenLeaf Huang
Oct 9, 2008·Advanced Drug Delivery Reviews·James D ByrneLisa Brannon-Peppas
Aug 5, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sumio ChonoLeaf Huang
Dec 18, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shyh-Dar LiLeaf Huang
Sep 6, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Andrew B SatterleeLeaf Huang
Aug 19, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lei MiaoLeaf Huang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Related Papers

Molecular Therapy : the Journal of the American Society of Gene Therapy
Shyh-Dar LiLeaf Huang
Journal of Controlled Release : Official Journal of the Controlled Release Society
Shyh-Dar LiLeaf Huang
Molecular Therapy : the Journal of the American Society of Gene Therapy
Shyh-Dar LiLeaf Huang
© 2021 Meta ULC. All rights reserved