PMID: 6974321Aug 7, 1981Paper

Anisatin, a potent GABA antagonist, isolated from Illicium anisatum

Neuroscience Letters
Y KudoK Yamada

Abstract

The neuropharmacological properties of anisatin were tested on the frog spinal cord and the crude synaptic membrane from rat brain. Anisatin (10(-5) M) reduced the amplitude of dorsal root potentials induced by stimulation of the adjacent dorsal root and presynaptic inhibition of the ventral root reflex. Anisatin shifted the dose-response curve for GABA-induced depolarization in the primary afferent terminal to the right and also reduced the maximum response to GABA. [3H]Muscimol binding to the crude synaptic membrane was not inhibited by anisatin. These results indicate that anisatin is a picrotoxin-like, non-competitive GABA-antagonist.

References

Dec 7, 1973·Brain Research·D R CurtisR M McCulloch

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