PMID: 9177881Mar 1, 1997Paper

Anisodamine restores bowel circulation in burn shock

Burns : Journal of the International Society for Burn Injuries
C Y ShengL X He

Abstract

In a group of eight burn patients with a mean of 65.3 +/- 17.4 per cent TBSA burn injury (range 50-90 per cent TBSA), accompanied by a mean of 43.5 +/- 18.9 per cent TBSA full-thickness injury, it was shown that the evidence of global hypovolaemia had disappeared at 12 h after the injury following aggressive fluid resuscitation, while there was still a subnormal pHi of stomach at 48 h. As a prolonged period of inadequacy of oxygen delivery to the intestine might result in impairment of the intestinal mucosal barrier function, and then endogenous endotoxaemia might ensue, it seems to be important to correct intestinal hypoxia as early as possible. Since the inadequate perfusion to the gut wall is due to selective vasoconstriction of the mesenteric vasculature, logic dictates that the use of a vasodilator is in order. Anisodamine, an anticholinergic drug, was then given in six burn patients with comparable burn size and amount of fluid replenishment with the eight patients in the control group. It was clearly demonstrated that gastric pHi returned to normal before 48 h after injury. Plasma endotoxin and TNF contents were measured, and they were significantly lower than control values after 72 h. In conclusion, it is believed that...Continue Reading

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Citations

Dec 28, 2006·Apoptosis : an International Journal on Programmed Cell Death·G GravanteG Sconocchia
Aug 5, 2000·Burns : Journal of the International Society for Burn Injuries·J ChaiX Jia
Jan 12, 2010·Journal of Burn Care & Research : Official Publication of the American Burn Association·Chengmei BaoZhiyong Sheng
Mar 27, 2001·The Journal of Trauma·B VenkateshJ Fraser
Jun 5, 2002·World Journal of Gastroenterology : WJG·Sen Hu, Zhi-Yong Sheng

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