Anisotropic light scattering of individual sickle red blood cells.

Journal of Biomedical Optics
Youngchan KimYongKeun Park

Abstract

We present the anisotropic light scattering of individual red blood cells (RBCs) from a patient with sickle cell disease (SCD). To measure light scattering spectra along two independent axes of elongated-shaped sickle RBCs with arbitrary orientation, we introduce the anisotropic Fourier transform light scattering (aFTLS) technique and measured both the static and dynamic anisotropic light scattering. We observed strong anisotropy in light scattering patterns of elongated-shaped sickle RBCs along its major axes using static aFTLS. Dynamic aFTLS analysis reveals the significantly altered biophysical properties in individual sickle RBCs. These results provide evidence that effective viscosity and elasticity of sickle RBCs are significantly different from those of the healthy RBCs.

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Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·YongKeun ParkMichael S Feld
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May 13, 2010·Journal of Biomedical Optics·YongKeun ParkMichael S Feld
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Sep 21, 2011·Trends in Biotechnology·Sangyeon ChoYongKeun Park

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Citations

Nov 7, 2015·Journal of the Mechanical Behavior of Biomedical Materials·K El Nady, J F Ganghoffer
Aug 20, 2016·Journal of Biophotonics·Hassaan MajeedGabriel Popescu
May 5, 2017·PloS One·Johannes MauerDmitry A Fedosov
Jul 18, 2019·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Xuantao SuBeihua Kong
Mar 13, 2014·Journal of Biomedical Optics·Matti KinnunenValery V Tuchin
Oct 10, 2013·Optics Express·Kyeoreh LeeYongkeun Park
Jun 30, 2012·Optics Letters·HyeonSeung YuYongKeun Park

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