Anisotropic Material Characterization of Human Cervix Tissue Based on Indentation and Inverse Finite Element Analysis

Journal of Biomechanical Engineering
Lei ShiK M Myers

Abstract

The cervix is essential to a healthy pregnancy as it must bear the increasing load caused by the growing fetus. Preterm birth is suspected to be caused by the premature softening and mechanical failure of the cervix. The objective of this paper is to measure the anisotropic mechanical properties of human cervical tissue using indentation and video extensometry. The human cervix is a layered structure, where its thick stromal core contains preferentially aligned collagen fibers embedded in a soft ground substance. The fiber composite nature of the tissue provides resistance to the complex three-dimensional loading environment of pregnancy. In this work, we detail an indentation mechanical test to obtain the force and deformation response during loading which closely matches in vivo conditions. We postulate a constitutive material model to describe the equilibrium material behavior to ramp-hold indentation, and we use an inverse finite element method based on genetic algorithm (GA) optimization to determine best-fit material parameters. We report the material properties of human cervical slices taken at different anatomical locations from women of different obstetric backgrounds. In this cohort of patients, the anterior internal ...Continue Reading

References

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Apr 8, 2010·Journal of Biomechanical Engineering·Kristin M MyersMichael House
Jul 12, 2011·Journal of Biomechanics·Srinivas C TadepalliPeter R Cavanagh
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Jul 31, 2012·Journal of the Mechanical Behavior of Biomedical Materials·Spencer P Lake, Victor H Barocas
Apr 9, 2013·Journal of the Mechanical Behavior of Biomedical Materials·Kristin Myers, Gerard A Ateshian
May 18, 2013·Journal of the Mechanical Behavior of Biomedical Materials·Yuan FengPhilip V Bayly
Sep 13, 2013·Journal of Biomechanical Engineering·Benjamin S Elkin, Barclay Morrison
Feb 20, 2014·Journal of the Mechanical Behavior of Biomedical Materials·Wang YaoKristin M Myers
Oct 5, 2014·American Journal of Obstetrics and Gynecology·Noelia M ZorkJoy Vink
Mar 31, 2015·Journal of Biomechanics·Kristin M MyersRonald J Wapner
Apr 7, 2015·Journal of Biomechanics·Kristin M MyersMichael House
May 15, 2015·Computer Methods in Biomechanics and Biomedical Engineering·M FernandezK Myers
Jan 19, 2016·Seminars in Fetal & Neonatal Medicine·Joy Vink, Helen Feltovich
May 12, 2016·American Journal of Obstetrics and Gynecology·Joy Y VinkGeorge Gallos
Mar 18, 2017·Journal of Biomechanical Engineering·Andrea R WesterveltKristin M Myers

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Citations

Dec 20, 2020·Journal of the Mechanical Behavior of Biomedical Materials·A CallejasG Rus
Nov 25, 2020·Biomaterials Science·Ines CadenaKaitlin C Fogg
Aug 9, 2020·Sensors·Antonio CallejasGuillermo Rus
Apr 22, 2021·Annals of Biomedical Engineering·Shuyang FangKristin M Myers

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