Anisotropic surface energetics and wettability of macroscopic form I paracetamol crystals

Langmuir : the ACS Journal of Surfaces and Colloids
Jerry Y Y HengDaryl R Williams

Abstract

Advancing (theta(A)) and receding (theta(R)) contact angles were measured with several probe liquids on the external facets (201), (001), (011), and (110) of macroscopic form I paracetamol crystals as well as the cleaved (internal) facet (010). For the external crystal facets, dispersive surface energies gamma(d) calculated from the contact angles were found to be similar (34 +/- 1 mJ/m(2)), while the polar components varied significantly. Cleaving the crystals exposed a more apolar (010) surface with very different surface properties, including gamma(d) = 45 +/- 1 mJ/m(2). The relative surface polarity (gamma(p)/gamma) of the facets in decreasing order was (001) > (011) > (201) > (110) > (010), which agreed with the fraction of exposed polar hydroxyl groups as determined from C and O 1s X-ray photoelectron spectroscopy (XPS) spectra, and could be correlated with the number of non-hydrogen-bonded hydroxyl groups per unit area present for each crystal facet, based on the known crystal structures. In conclusion, all facets of form I paracetamol crystals examined exhibited anisotropic wetting behavior and surface energetics that correlated to the presence of surface hydroxyl groups.

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Citations

Jul 20, 2006·Pharmaceutical Research·Jerry Y Y HengDaryl R Williams
Jan 20, 2007·AAPS PharmSciTech·Jerry Y Y HengDaryl R Williams
Jan 24, 2007·Journal of Pharmaceutical Sciences·Jerry Y Y HengDaryl R Williams
Mar 17, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Vibha PuriArvind K Bansal
Jun 20, 2008·Journal of Colloid and Interface Science·Lennart LindforsUlf Olsson
Jun 15, 2014·International Journal of Pharmaceutics·Umang V ShahJerry Y Y Heng
Jun 5, 2012·International Journal of Pharmaceutics·Thanh Huong Hoang ThiMarie-Pierre Flament
Sep 5, 2012·International Journal of Pharmaceutics·Kalyana C PingaliAdrian B Mann
Mar 6, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Preksha LaadArvind Kumar Bansal
Apr 30, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A QuigleyD R Williams
Jul 6, 2016·Pharmaceutical Research·Changquan Calvin Sun
Sep 16, 2016·The AAPS Journal·Robert R SmithJerry Y Y Heng
Jul 3, 2020·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Toshiaki HatanakaEtsuo Yonemochi
Sep 3, 2019·Chemical & Pharmaceutical Bulletin·Daisuke IoharaFumitoshi Hirayama
Mar 21, 2018·Pharmaceutical Research·Eftychios HadjittofisJerry Y Y Heng
Aug 27, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Bin SuQinghua Lu
Aug 5, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Rafael TadmorWesley R Hoffer
Aug 6, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Pirre P Ylä-MäihäniemiDaryl R Williams
Mar 12, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Eric M GrzelakJeffrey R Errington
Apr 27, 2021·Organic Process Research & Development·Muhid ShahidChris Price
Dec 23, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Shyamal C DasPeter J Stewart
Jun 28, 2019·Molecular Pharmaceutics·Dnyaneshwar P KaleArvind K Bansal

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