Ankle-brachial index, cognitive impairment and cerebrovascular disease in a chinese population

Neuroepidemiology
Saima HilalMohammad K Ikram

Abstract

Previous studies have assessed the association between ankle-brachial index (ABI) and cognition, mainly using brief cognitive tests. We investigated whether ABI was associated with cognition independent of neuroimaging markers of cerebrovascular disease. Chinese subjects (n = 278, aged ≥60 years) were recruited from the ongoing Epidemiology of Dementia in Singapore (EDIS) Study. Ankle and brachial blood pressures were measured, and low ABI was defined as ≤0.9. A neuropsychological battery was utilized to determine cognition. Cognitive impairment no dementia (CIND) and dementia were diagnosed according to standard diagnostic criteria. Magnetic resonance imaging (MRI) was used to obtain semiquantitative and quantitative markers of cerebrovascular disease and atrophy. A low ABI was related to the presence of intracranial stenosis (odds ratio, OR = 1.71; 95% confidence interval, CI: 1.13-2.59), but not with the presence of infarcts, microbleeds or grey matter, white matter and white matter lesion volumes. Furthermore, a low ABI was associated with poorer overall cognitive function and CIND-moderate/dementia (OR = 2.26; 95% CI: 1.11-4.59), independent of cardiovascular risk factors, and the MRI markers related to cerebrovascular dis...Continue Reading

References

Apr 15, 2015·Journal of the American Medical Directors Association·Mark A EspelandLIFE Study Group
Sep 25, 2015·Journal of Alzheimer's Disease : JAD·Saima HilalMohammad K Ikram
Dec 3, 2014·Neuroscience Letters·Yi-Ting OngMohammad K Ikram
Jun 11, 2015·Medicine·Saima HilalMohammad K Ikram
Mar 21, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Saima HilalChristopher Chen
May 26, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·Yu A KolmykovaA N Sumin

Related Concepts

Mini-mental State Examination
Biologic Segmentation
Arterial System
Magnetic Resonance Angiography
Hemoglobin, Glycosylated
Magnetic Resonance Imaging
Asymptomatic Diseases
Ankle
Ankle Joint Structure
Systolic Blood Pressure Measurement

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