Anna-Monika-Prize paper. The hypothalamic-pituitary-adrenal system in depression

Pharmacopsychiatry
I Heuser

Abstract

Patients with depression frequently have symptom clusters which point strongly to involvement of the hypothalamic-pituitary-adrenal (HPA) system as a relay station between neurocircuitries in the brain and peripheral hormone and autonomic nervous function. It has been proposed that this increased, state-dependent hyperactivity of the HPA-system in depression is probably initiated and/or maintained by the combination of enhanced central production of CRH and desensitization of the binary, glucocorticoid receptor binding system in the hippocampus, which is the central regulator of HPA system activity. In a first series of studies a refined neuroendocrine test to probe the integrity of HPA system status--the combined dexamethasone suppression/CRH challenge (DEX/CRH) test--was developed and the differential effects of aging and depressed psychopathology on DEX/CRH test outcome were described. In a second set of studies, the chronological relationship between improvement of psychopathology in depressed patients treated with antidepressants and normalization of the disturbed HPA system function in these patients was further elucidated. Given the evidence from animal studies, we conclude that antidepressants induce an up-regulation of...Continue Reading

Citations

Dec 3, 2008·Archives of Pediatrics & Adolescent Medicine·Lorah D DornSusannah Grimes
Mar 31, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S J DiemUNKNOWN Osteoporotic Fractures in Men (MrOS) Research Group
Dec 22, 1999·Biological Psychiatry·J F LópezS J Watson
Jul 7, 2001·Psychiatry Research·F LederbogenM Deuschle
Apr 25, 2003·European Psychiatry : the Journal of the Association of European Psychiatrists·F LederbogenM Deuschle
Mar 18, 2003·Journal of Clinical Psychopharmacology·Thomas NickelFlorian Holsboer
Aug 10, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Kai G KahlUlrich Schweiger
May 20, 2008·Physiology & Behavior·Mark E WilsonTimothy J Bartness
Feb 23, 2007·International Journal of Clinical Practice·O AltindagZ Deveci
Jun 1, 2007·Journal of the American Geriatrics Society·Susan J DiemUNKNOWN Study of Osteoporotic Fractures
Aug 16, 2008·The Mount Sinai Journal of Medicine, New York·Srijan Sen, Gerard Sanacora
Nov 14, 2007·Depression and Anxiety·Orla Patricia HornungIon Anghelescu
May 24, 2006·Psychoneuroendocrinology·Sabra S InslichtAndrew Baum
Feb 25, 2006·Journal of Psychiatric Research·Bettina Weber-HamannMichael Deuschle
Jun 1, 2005·Medical Hypotheses·Leo Sher
Apr 1, 2006·Acta Neuropsychiatrica·Lana J WilliamsMichael Berk
Feb 15, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R AndreatiniF G Graeff
Nov 12, 2011·International Journal of Psychiatry in Medicine·Burkhard LudescherFritz Schick
Dec 17, 2008·International Journal of Psychiatry in Medicine·Burkhard LudescherGerhard W Eschweiler
Dec 24, 2009·Evidence-based Complementary and Alternative Medicine : ECAM·Lei AnYun-Feng Li
Mar 17, 2000·The Journal of Clinical Endocrinology and Metabolism·B WeberI Heuser

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