Annexin 2 and hemorrhagic disorder in vascular intimal carcinomatosis

Thrombosis Research
Seiji MadoiwaYoichi Sakata

Abstract

Vascular intimal carcinomatosis refers to a characteristic tumor proliferation on vascular intima that replaces normal endothelium. This pathological event of unknown cause is quite different from tumor thrombotic microangiopathy due to the absence of thrombi on the tumor cell surfaces. We analyzed renal transitional cell carcinoma cases with metastasis to the main pulmonary arteries and marked hyperfibrino(geno)lysis. The fibrinogen-derived products from patients' plasma were identified as D1A/gamma, D1/gamma, and D1/beta by immunoblotting with the NH2-terminus of the fragment D specific antibody JIF-23. In all cases, the neoplastic cells with vascular intimal carcinomatosis were stained positive for anti-human annexin 2, which is a unique cell surface co-receptor for plasminogen and tissue-type plasminogen activator. In contrast, normal renal pelvic mucosa or renal transitional cell carcinoma without vascular intimal carcinomatosis did not express any annexin 2. The isolated transitional cell carcinoma cells contained annexin 2 mRNA and expressed its protein. Anti-annexin 2 antibody and transfection of annexin 2 small interfering RNA into these carcinoma cells significantly inhibited tissue-type plasminogen activator dependen...Continue Reading

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Citations

Oct 7, 2016·Thrombosis Journal·Hidesaku AsakuraUNKNOWN DIC subcommittee of the Japanese Society on Thrombosis and Hemostasis
Jul 17, 2019·Current Drug Targets·Tetsumei UranoFrancis J Castellino
Feb 28, 2018·Spine Surgery and Related Research·Hirokazu InoueKatsushi Takeshita
Nov 12, 2020·International Journal of Hematology·Shinya Yamada, Hidesaku Asakura

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