Annexin A1 Is a Physiological Modulator of Neutrophil Maturation and Recirculation Acting on the CXCR4/CXCL12 Pathway

Journal of Cellular Physiology
Isabel Daufenback MachadoSandra H Farsky

Abstract

Neutrophil production and traffic in the body compartments is finely controlled, and the strong evidences support the role of CXCL12/CXCR4 pathway on neutrophil trafficking to and from the bone marrow (BM). We recently showed that the glucocorticoid-regulated protein, Annexin A1 (AnxA1) modulates neutrophil homeostasis and here we address the effects of AnxA1 on steady-state neutrophil maturation and trafficking. For this purpose, AnxA1(-/-) and Balb/C wild-type mice (WT) were donors of BM granulocytes and mesenchymal stem cells and blood neutrophils. In vivo treatments with the pharmacological AnxA1 mimetic peptide (Ac2-26) or the formyl peptide receptor (FPR) antagonist (Boc-2) were used to elucidate the pathway of AnxA1 action, and with the cytosolic glucocorticoid antagonist receptor RU 38486. Accelerated maturation of BM granulocytes was detected in AnxA1(-/-) and Boc2-treated WT mice, and was reversed by treatment with Ac2-26 in AnxA1(-/-) mice. AnxA1 and FPR2 were constitutively expressed in bone marrow granulocytes, and their expressions were reduced by treatment with RU38486. Higher numbers of CXCR4(+) neutrophils were detected in the circulation of AnxA1(-/-) or Boc2-treated WT mice, and values were rescued in Ac2-26-...Continue Reading

References

Jan 1, 1976·International Review of Cytology·A J Friedenstein
Sep 1, 1976·The Journal of Clinical Investigation·J T DanceyC A Finch
Sep 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A I Caplan
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·S S HoogM Lewis
Oct 2, 1998·British Journal of Pharmacology·E SolitoF Russo-Marie
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
May 18, 2004·Experimental Hematology·Elisabeth H JavazonAlan W Flake
Feb 24, 2006·Molecular and Cellular Endocrinology·Danielle M H CavalcantiSandra H P Farsky
Feb 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Mark D TrottierPamela J Fraker
May 30, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rebecca C Furze, Sara M Rankin
Oct 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sibylle von Vietinghoff, Klaus Ley
Dec 24, 2008·Nature Reviews. Immunology·Mauro Perretti, Fulvio D'Acquisto
Jan 9, 2009·Immunology·Rebecca C Furze, Sara M Rankin
Jul 14, 2010·Trends in Immunology·Charlotte SummersEdwin R Chilvers
Nov 10, 2010·Hypertension·Ah-Mee ParkYuichiro J Suzuki
Nov 26, 2010·Immunity·Niels Borregaard
Oct 1, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jesmond DalliSara M Rankin
Jul 31, 2012·Advances in Hematology·Taylor W Starnes, Anna Huttenlocher
Sep 12, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Felicity N E GavinsJulia C Buckingham
Nov 13, 2012·PloS One·Valentina BizzarroAntonello Petrella
Jan 2, 2013·Proceedings of the National Academy of Sciences of the United States of America·Enrico CristanteEgle Solito
Apr 11, 2013·Journal of Innate Immunity·Natasha Strydom, Sara M Rankin
Apr 30, 2013·Journal of Leukocyte Biology·Tamar TakLeo Koenderman
May 7, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ana P GirolSonia M Oliani
Oct 10, 2013·Cellular Signalling·Cosimo Walter D'AcuntoTomas Ruml
Sep 4, 2014·American Journal of Physiology. Endocrinology and Metabolism·Isabel Daufenback MachadoSandra Helena Poliselli Farsky
Feb 27, 2015·Journal of Leukocyte Biology·Elizabeth A Harvie, Anna Huttenlocher
Mar 13, 2015·PLoS Pathogens·Philipp KrugerDominik Hartl
Apr 26, 2015·Seminars in Immunology·Sarah E Headland, Lucy V Norling
Jul 1, 2015·Frontiers in Immunology·Takashi Nagasawa

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Citations

Jun 19, 2016·Biological Chemistry·Thomas GrewalCarles Rentero
Nov 9, 2017·Journal of Cellular Physiology·Cristina B HebedaSandra H P Farsky
Apr 3, 2020·Cellular & Molecular Immunology·Mieke MetzemaekersPaul Proost
Jul 13, 2018·The Journal of Experimental Medicine·Sara E MeyerH Leighton Grimes
May 23, 2018·Cell Communication and Signaling : CCS·Jingwen WangJianwu Tang
Jan 29, 2019·Frontiers in Immunology·Louise M InceChristoph Scheiermann
Sep 27, 2020·International Journal of Molecular Sciences·Pablo ScharfSandra Helena Poliselli Farsky
Jan 18, 2021·Basic & Clinical Pharmacology & Toxicology·Jiyang XuHong Zhang
Feb 25, 2021·Clínica e investigación en arteriosclerosis : publicación oficial de la Sociedad Española de Arteriosclerosis·Nerea Méndez-BarberoLuis Miguel Blanco-Colio
Apr 4, 2021·International Journal of Molecular Sciences·Thomas GrewalUrsula Rescher

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