Feb 11, 2014

Annexin A11 in disease

Clinica Chimica Acta; International Journal of Clinical Chemistry
Jiasheng WangFrederick Greenaway

Abstract

Ubiquitously expressed in many cell types, annexin A11 (Anxa11) is a member of the multigene family of Ca(2+)-regulated phospholipid-dependent and membrane-binding annexin proteins. Studies have shown that Anxa11 plays an important role in cell division, Ca(2+) signaling, vesicle trafficking and apoptosis. The deregulation and mutation of Anxa11 are involved in systemic autoimmune diseases, sarcoidosis and the development, chemoresistance and recurrence of cancers. Malfunction of Anxa11 may lead to or enhance the metastasis, invasion and drug resistance of cancers through the platelet-derived growth factor receptor (PDGFR) pathway and/or the mitogen-activated protein kinase (MAPK)/p53 pathway. In a variety of diseases, Anxa11 is most commonly reported to function through interactions with apoptosis-linked gene-2 protein (ALG-2) and/or calcyclin (S100A6). Although it has been little studied, Anxa11 is a promising biomarker for the diagnosis, treatment and prognosis of certain diseases. In this review, the associations of Anxa11 with Ca(2+)-regulated exocytosis, cytokinesis, sex differentiation, autoimmune diseases, thrombolysis and cancers are summarized and interpreted.

  • References66
  • Citations9

References

Mentioned in this Paper

Vertebrates
Annexin A11
Ovarian Diseases
PDGFRB wt Allele
Noninfiltrating Intraductal Carcinoma
Biochemical Pathway
Autoantibodies
CA2 gene
Benign Neoplasm of Testis
Middle Region of Body

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