Abstract
This study aimed to investigate the role of ANXA13 in lung adenocarcinoma (LUAD) growth, migration, and the underlying mechanisms. Firstly, in the TCGA dataset for LUAD, ANXA13 is found to be highly expressed in patients with LUAD and high expression of ANXA13 predicted poor outcomes in LUAD patients. Consistently, the data of qRT-PCR showed that the expression of ANXA13 was higher in LUAD cell lines (Calu-3, LTEP-a-2, and NCI-H1395) than that in normal lung cell line BEAS2B. Then, we performed gain- and loss of function of ANXA13 in NCI-H1395 and Calu-3 cells, respectively. The results displayed that deficiency of ANXA13 suppresses cell proliferation, invasion, and migration in Calu-3 cells and overexpression of ANXA13 augments cell proliferation, invasion, and migration in NCI-H1395 cells. Finally, it was found that silencing of ANXA13 obviously raised the protein expression levels of E-cadherin and reduced the protein levels of N-cadherin, Vimentin, and Snail in Calu-3 cells whereas overexpression of ANXA13 obviously receded the protein expression levels of E-cadherin and enhanced the protein levels of N-cadherin, Vimentin, and Snail in NCI-H1395 cells. This study analyzed the biological effects of ANXA13 in LUAD cells, indi...Continue Reading
References
Mar 16, 2004·Cancer Science·Jun Yokota, Takashi Kohno
Jun 2, 2005·Nature Reviews. Molecular Cell Biology·Volker GerkeStephen E Moss
Nov 15, 2007·Cytogenetic and Genome Research·M van DuinH van Dekken
May 5, 2012·Seminars in Cancer Biology·Christina Scheel, Robert A Weinberg
Jan 25, 2013·Nature Reviews. Cancer·Bram De Craene, Geert Berx
Jan 30, 2013·International Journal of Molecular Sciences·María Antonia LizarbeJavier Turnay
Dec 17, 2015·Advances in Experimental Medicine and Biology·Lindsey A TorreAhmedin Jemal
Jan 16, 2016·Clinical Science·Zied BoudhraaFrançoise Degoul
Apr 23, 2016·Frontiers in Bioscience (Landmark Edition)·Houshan YaoWeijun Wang
Dec 24, 2016·The International Journal of Biological Markers·Rong BiaoxueGao Wenlong
Mar 31, 2017·Virchows Archiv : an International Journal of Pathology·Julia KälschHideo A Baba
Apr 5, 2017·Anticancer Research·Nikolaos TsoukalasStamatios Theocharis
Apr 21, 2017·Oncotarget·Guozhong JiangKuisheng Chen
Aug 10, 2017·Scientific Reports·Srinivasulu Yerukala Sathipati, Shinn-Ying Ho
Sep 10, 2017·Journal of Experimental & Clinical Cancer Research : CR·Xiaomin FengZhimin He
Dec 7, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alessandra M RichardsonAdam I Marcus
May 1, 2018·Oral Oncology·Joel P JosephArikketh Devi
Jul 10, 2018·Scientific Reports·Theresa Louise BoyeAdam Cohen Simonsen
Sep 13, 2018·CA: a Cancer Journal for Clinicians·Freddie BrayAhmedin Jemal
Jan 6, 2019·The Journal of Biological Chemistry·Kathryn M McCullochT M Iverson
Apr 17, 2019·OncoTargets and Therapy·Yong TangGuilin Yin
Apr 24, 2019·Cell Proliferation·Chengtao YuWang Qian
Jul 13, 2019·BMC Cancer·Jing SongQi Wang
Jul 25, 2019·International Journal of Molecular Sciences·Thomas GrewalChrista Buechler
Aug 17, 2019·Journal of Cancer·Qing MaYe Gu
Sep 3, 2019·Journal of Translational Medicine·Rui GouBei Lin
Sep 8, 2019·EBioMedicine·Rongqi SunZongli Zhang
Sep 12, 2019·Communications Biology·Nusrat J EpsiAntonina Mitrofanova
Jan 12, 2020·Communications Biology·Nusrat J EpsiAntonina Mitrofanova