Annexin A2 is SUMOylated on its N-terminal domain: regulation by insulin

FEBS Letters
Danielle CaronRobert L Faure

Abstract

Insulin receptor (IR) endocytosis requires a remodelling of the actin cytoskeleton. We show here that ANXA2 is SUMOylated at the K10 located in a non-consensus SUMOylation motif in the N-terminal domain. The Y24F mutation decreased the SUMOylation signal, whereas insulin stimulation increased ANXA2 SUMOylation. A survey of protein SUMOylation in hepatic Golgi/endosome (G/E) fractions after insulin injections revealed the presence of a SUMOylation pattern and confirmed the SUMOylation of ANXA2. The construction of an IR/ANXA2/SUMO network (IRASGEN) in the G/E context reveals the presence of interacting nodes whereby SUMO1 connects ANXA2 to actin and microtubule-mediated changes in membrane topology. Heritable variants associated with type 2 diabetes represent 41% of the IRASGEN thus pointing out the physio-pathological importance of this subnetwork.

References

Jan 1, 1990·The Journal of Cell Biology·J J DohertyJ J Bergeron
Jun 14, 1988·Biochemistry·D D Schlaepfer, H T Haigler
Nov 28, 1988·The American Journal of Medicine·W C DuckworthD E Peavy
Mar 10, 1995·The Journal of Biological Chemistry·J L Carpentier, D McClain
Oct 19, 1999·Microscopy Research and Technique·T TsakiridisG P Downey
Feb 17, 2000·Trends in Cell Biology·S Ellis, H Mellor
Aug 18, 2001·Current Biology : CB·C J MerrifieldS E Moss
Mar 28, 2002·Physiological Reviews·Volker Gerke, Stephen E Moss
Apr 26, 2002·Cell Death and Differentiation·M L Coleman, M F Olson
Jul 27, 2002·Annual Review of Cell and Developmental Biology·Matthew D Welch, R Dyche Mullins
Mar 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Wesley FarrisSuzanne Guenette
Oct 23, 2003·Annual Review of Cell and Developmental Biology·Asa E Y Engqvist-Goldstein, David G Drubin
Dec 31, 2003·Developmental Biology·Myrto Raftopoulou, Alan Hall
May 5, 2004·The Journal of Biological Chemistry·Ram Kumar MishraRohit Mittal
Jul 15, 2004·The Journal of Biological Chemistry·Alejandro BalbisBarry I Posner
Jul 21, 2004·Traffic·Matthew J HayesStephen E Moss
Dec 21, 2005·Nature Reviews. Molecular Cell Biology·Joshua Zimmerberg, Michael M Kozlov
Apr 18, 2006·Nature Medicine·Marie-Julie DuboisAndré Marette
May 11, 2006·The Biochemical Journal·Liliana Santamaria-KisielGary S Shaw
Aug 15, 2006·Current Opinion in Cell Biology·Matthew C JonesJim C Norman
Feb 3, 2007·Molecular Biology of the Cell·Jaakko Saraste, Bruno Goud
Jun 6, 2007·Traffic·Clare E Futter, Ian J White
Jan 16, 2008·Sub-cellular Biochemistry·M J HayesS E Moss
May 30, 2008·The Journal of Biological Chemistry·Malik ZiboucheJesus Ayala-Sanmartin
Nov 8, 2008·The Journal of Biological Chemistry·Etienne Morel, Jean Gruenberg
Nov 22, 2008·Biochimica Et Biophysica Acta·Matthew J HayesStephen E Moss
Jan 16, 2009·Biochemical Society Transactions·Emily R EdenClare E Futter

❮ Previous
Next ❯

Citations

Aug 16, 2018·PloS One·Rose CairnsThomas Grewal
Sep 27, 2018·Molecular Biology of the Cell·Anneliese C StrizPamela L Tuma
Jul 25, 2019·International Journal of Molecular Sciences·Thomas GrewalChrista Buechler
Feb 13, 2019·Reviews in Medical Virology·Isah Abubakar AliyuHui-Yee Chee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.