Annexin A3 as a Prognostic Biomarker for Breast Cancer: A Retrospective Study

BioMed Research International
Tao ZhouJiajie Shi

Abstract

To validate the correlation between ANXA3 expression and prognosis in breast cancer, a retrospective study encompassing 309 breast cancer patients was performed. The expression of ANXA3 was determined by the immunohistochemical examination of tissue sections by the Max Vision™ method. The ANXA3 levels in the patient samples were validated for the prognosis based on age, menopause status, tumor size, tumor node, metastasis stage, the number of lymphatic metastases, oncology grade, and molecular subtyping. An elevated expression of ANXA3 was detected in breast cancer samples, compared to adjacent tissue samples, and significant correlation depending on the number of lymphatic metastases (P= 0.001) and histological grade (P= 0.004) was observed. The number of lymphatic metastases and ANXA3 expression were identified as independent risk factors affecting the disease-free survival and overall survival. Significantly (P< 0.002) higher level of ANXA3 was detected in triple-negative breast cancer compared to other subtypes. There was no significant (P> 0.05) change in the expression of ANXA3 with respect to age, menopausal status, tumor size, and clinical stage. The findings implicate the expression of ANXA3 with the natural progressio...Continue Reading

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Citations

Apr 12, 2019·Interdisciplinary Sciences, Computational Life Sciences·Anil Kumar TomarBishwajit Kundu
Sep 17, 2019·Molecular Medicine Reports·Xinxin ZengZhaoxu Li
Jan 19, 2021·ACS Biomaterials Science & Engineering·Shahriare HossainMenake E Piyasena
Mar 7, 2021·Journal of Personalized Medicine·Noshad PeyravianEhsan Nazemalhosseini Mojarad
Aug 7, 2021·Frontiers in Molecular Biosciences·Liu YangSong Qu
Oct 30, 2021·Oncology Letters·Chao LiuXue Feng

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Methods Mentioned

BETA
ELISA

Software Mentioned

SPSS

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