Annexin A3 expression increases in hepatocytes and is regulated by hepatocyte growth factor in rat liver regeneration

Journal of Biochemistry
Mizuho HarashimaShingo Niimi

Abstract

Annexin (Anx) A3 increases and plays important roles in the signalling cascade in hepatocyte growth in cultured hepatocytes. However, no information is available on its expression and role in rat liver regeneration. In the present study, AnxA3 expression was investigated to determine whether it also plays a role in the signalling cascade in rat liver regeneration. AnxA3 protein and mRNA level both increase in liver after administration of carbon tetrachloride (CCl4) or 70% partial hepatectomy. AnxA3 protein level increases in isolated parenchymal hepatocytes, but not in non-parenchymal liver cells, in these rat liver regeneration models. AnxA3 mRNA increases in hepatocytes after CCl4 administration. Anti-hepatocyte growth factor antibody suppresses this increase in AnxA3 mRNA level. These results demonstrate that AnxA3 expression increases in hepatocytes through a hepatocyte growth factor-mediated pathway in rat liver regeneration models, suggesting that AnxA3 plays an important role in the signalling cascade in rat liver regeneration.

Citations

Jun 12, 2012·Proteome Science·Xiaofang JiaLijun Zhang
Nov 23, 2012·Proteome Science·Sheng-Ta TsaiChung-Hsuan Chen
Aug 2, 2011·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Bin ShiLaura Sepp-Lorenzino
Mar 26, 2015·PloS One·Katharina BertramAgnes Görlach
Dec 17, 2016·Biochimica Et Biophysica Acta. Molecular Cell Research·Carlos EnrichThomas Grewal
Dec 8, 2010·Proteomics. Clinical Applications·Eun-Jung JungSoon-Chan Hong
Dec 2, 2017·Journal of Veterinary Internal Medicine·V M Eulenberg, J A Lidbury
Mar 7, 2021·Journal of Personalized Medicine·Noshad PeyravianEhsan Nazemalhosseini Mojarad
Oct 30, 2021·Oncology Letters·Chao LiuXue Feng

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