Annexin A3 in sepsis: novel perspectives from an exploration of public transcriptome data.

Immunology
Mohammed ToufiqMathieu Garand

Abstract

According to publicly available transcriptome datasets, the abundance of Annexin A3 (ANXA3) is robustly increased during the course of sepsis; however, no studies have examined the biological significance or clinical relevance of ANXA3 in this pathology. Here we explored this interpretation gap and identified possible directions for future research. Based on reference transcriptome datasets, we found that ANXA3 expression is restricted to neutrophils, is upregulated in vitro after exposure to plasma obtained from septic patients, and is associated with adverse clinical outcomes. Secondly, an increase in ANXA3 transcript abundance was also observed in vivo, in the blood of septic patients in multiple independent studies. ANXA3 is known to mediate calcium-dependent granules-phagosome fusion in support of microbicidal activity in neutrophils. More recent work has also shown that ANXA3 enhances proliferation and survival of tumour cells via a Caspase-3-dependent mechanism. And this same molecule is also known to play a critical role in regulation of apoptotic events in neutrophils. Thus, we posit that during sepsis ANXA3 might either play a beneficial role, by facilitating microbial clearance and resolution of the infection; or a d...Continue Reading

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Datasets Mentioned

BETA
GSE49755
GSE49758
GSE49757
GSE60424
GSE13015
GSE49756
GSE30119
GSE64457

Methods Mentioned

BETA
Assay
RNAseq

Software Mentioned

Excel
Gene Expression Browser web application ( GXB
GXB

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