Annexin A5 prevents amyloid-β-induced toxicity in choroid plexus: implication for Alzheimer's disease.

Scientific Reports
Fernando BartolomeEva M Carro

Abstract

In Alzheimer's disease (AD) amyloid-β (Aβ) deposits may cause impairments in choroid plexus, a specialised brain structure which forms the blood-cerebrospinal fluid (CSF) barrier. We previously carried out a mass proteomic-based study in choroid plexus from AD patients and we found several differentially regulated proteins compared with healthy subjects. One of these proteins, annexin A5, was previously demonstrated implicated in blocking Aβ-induced cytotoxicity in neuronal cell cultures. Here, we investigated the effects of annexin A5 on Aβ toxicity in choroid plexus. We used choroid plexus tissue samples and CSF from mild cognitive impairment (MCI) and AD patients to analyse Aβ accumulation, cell death and annexin A5 levels compared with control subjects. Choroid plexus cell cultures from rats were used to analyse annexin A5 effects on Aβ-induced cytotoxicity. AD choroid plexus exhibited progressive reduction of annexin A5 levels along with progressive increased Aβ accumulation and cell death as disease stage was higher. On the other hand, annexin A5 levels in CSF from patients were found progressively increased as the disease stage increased in severity. In choroid plexus primary cultures, Aβ administration reduced endogenou...Continue Reading

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Citations

Aug 19, 2021·Apoptosis : an International Journal on Programmed Cell Death·Akvile HaeckelEyk Schellenberger

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Methods Mentioned

BETA
ELISA
transgenic
fluorescence microscopy

Software Mentioned

Volocity
GraphPad Prism
Image Studio Lite
GraphPad
Andor
ARRIVA

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