Annexin A7 modulates BAG4 and BAG4-binding proteins in mitochondrial apoptosis

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Yue DuJianwu Tang

Abstract

Annexin A7 caused an anti-apoptosis phenotype in mouse hepatocarcinoma cells. Yet, the underlying mechanism remains unclear. In this study, we found that Annexin A7 had an inhibitory effect on the mitochondrial Cytochrome C release and Caspase-3 cleavage. Furthermore, Annexin A7 was identified to form a complex with BAG4 which is a negative regulator of apoptosis. Moreover, Annexin A7 was positively correlated with the protein levels of BAG4, Hsp70 and Bcl-2. Both Hsp70 and Bcl-2 bind BAG4 and inhibit Cytochrom C dependent activation of Caspase-3. Taken together, our study indicated Annexin A7 modulated BAG4 and BAG4-binding proteins in mitochondrial apoptosis.

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Jan 1, 2014·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lin SongJian-Wu Tang
Feb 5, 2014·Biochemical and Biophysical Research Communications·Yue DuJianwu Tang

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Citations

Feb 29, 2020·International Journal of Molecular Sciences·Manuel Alvarez-RodriguezHeriberto Rodriguez-Martinez
Oct 2, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiaoying HeJunying Miao
May 25, 2016·World Journal of Gastroenterology : WJG·Dong ChenXi Jin
Feb 9, 2017·Molecular and Cellular Biochemistry·Weihua YeZhidong Zhang
Feb 1, 2020·Pharmacology & Therapeutics·Elena MariottoSanja Aveic
Aug 3, 2021·Journal of Cellular Biochemistry·Liberato MarzulloVladimir N Uversky

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