Annexin A8 displays unique phospholipid and F-actin binding properties

FEBS Letters
Verena GoebelerUrsula Rescher

Abstract

Annexin A8 is a poorly characterized member of the annexin family of Ca2+-regulated membrane binding proteins. Initially only identified at the cDNA level it had been tentatively linked to acute promyelocytic leukaemia (APL) due to its high and regulated expression in APL-derived cells. Here we identify unique properties of the annexin A8 protein. We show that it binds Ca2+-dependently and with high specificity to phosphatidylinositol (4,5)-bisphosphate (PtdIns(4,5)P2) and is also capable of interacting with F-actin. In line with these characteristics annexin A8 is recruited to F-actin-associated PtdIns(4,5)P2-rich membrane domains formed in HeLa cells upon infection with non-invading enteropathogenic Escherichia coli. These properties suggest a role of annexin A8 in the organization of certain actin-associated membrane domains.

References

Jul 13, 1992·FEBS Letters·R B Pepinsky, R Hauptmann
Oct 1, 1987·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J R Glenney
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·K G JarvisJ B Kaper
Mar 15, 1994·The Biochemical Journal·M JostV Gerke
Jul 25, 1994·FEBS Letters·C P ReutelingspergerA Tiebosch
Oct 14, 2000·Annual Review of Cell and Developmental Biology·D L GoosneyB B Finlay
Nov 9, 2000·The Journal of Biological Chemistry·N R Filipenko, D M Waisman
Jan 9, 2001·Trends in Cell Biology·F Frischknecht, M Way
Mar 28, 2002·Physiological Reviews·Volker Gerke, Stephen E Moss
Jul 21, 2004·Traffic·Matthew J HayesStephen E Moss
Dec 14, 2004·Biochimica Et Biophysica Acta·R O MorganM P Fernandez

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Citations

Apr 5, 2008·Pflügers Archiv : European journal of physiology·Grazia TammaGiovanna Valenti
Nov 4, 2006·Journal of Molecular Histology·Fabian RunkelThomas Franz
Oct 17, 2008·Molecular Biology of the Cell·Verena GoebelerUrsula Rescher
Jan 30, 2013·International Journal of Molecular Sciences·María Antonia LizarbeJavier Turnay
May 30, 2013·Cellular and Molecular Life Sciences : CMLS·Nina QuiskampUrsula Rescher
Oct 21, 2014·Chemical Research in Toxicology·Nina E WezynfeldTomasz Frączyk
Apr 22, 2009·Cellular and Molecular Life Sciences : CMLS·Katia MonastyrskayaAnnette Draeger
Jun 15, 2012·Molecular Membrane Biology·Joanna Bandorowicz-PikulaSlawomir Pikula
Mar 26, 2016·Frontiers in Immunology·Julie Guignot, Guy Tran Van Nhieu
Feb 24, 2011·Journal of Cellular Physiology·Tania N CrottiKevin P McHugh
Sep 25, 2012·Molecular Carcinogenesis·Harumi HataToshio Nakadate
Sep 19, 2014·Biochemical Society Transactions·Marina E MonteiroFábio Fernandes
May 29, 2016·Biological Trace Element Research·Deepa GandhiSaravanadevi Sivanesan
Jan 7, 2017·Cell Adhesion & Migration·Nicole HeitzigUrsula Rescher
Apr 20, 2017·International Journal of Molecular Sciences·Dorota Konopka-Postupolska, Greg Clark
Nov 30, 2007·Journal of Cellular Biochemistry·Agnieszka Strzelecka-KiliszekJoanna Bandorowicz-Pikula
Jul 25, 2019·International Journal of Molecular Sciences·Thomas GrewalChrista Buechler
Aug 10, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sebastian SchloerUrsula Rescher
Jul 2, 2016·Biological Chemistry·Alexander KuehnlUrsula Rescher
May 15, 2018·International Journal of Molecular Sciences·Carles RenteroCarlos Enrich
Apr 23, 2009·Cellular Signalling·Thomas Grewal, Carlos Enrich
Oct 27, 2017·Gene Expression·Simone BrivioMario Strazzabosco

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