Annexin expression in inflammatory myopathies

Muscle & Nerve
Stefan Probst-CousinDieter Heuss

Abstract

The pathogenesis of the inflammatory myopathies is still unclear, making their treatment largely empirical. Improved understanding of the molecular mechanisms of inflammatory muscle injury may, however, lead to the development of more specific immunotherapies. To elucidate a possible pathogenic contribution of calcium-binding proteins such as the annexins, we immunohistochemically investigated muscle biopsy specimens from patients with dermatomyositis (10 cases), polymyositis (9 cases), and inclusion-body myositis (4 cases), compared to control cases comprising sarcoid myopathy (3 cases), Duchenne muscular dystrophy (DMD; 4 cases), and normal muscle (3 cases). We found expression of annexins A1, A2, A4, and A6 in the vascular endothelium of all cases. Myofibers expressed annexins A5, A6, and A7 diffusely and weakly in the cytosol, whereas annexins A5 and A7 were also particularly localized to the sarcolemma. In the inflammatory myopathies, in areas of myonecrosis in DMD, and in granulomatous lesions of sarcoid myopathy, reactivity of annexins A1, A2, A4, A5, and A6 was observed in macrophages and T-lymphocytes. Whereas the latter annexins appear to be nonspecific indicators of activation, annexin A1 upregulation may represent e...Continue Reading

References

Jan 1, 1992·Progress in Brain Research·H B PollardA L Burns
Sep 1, 1991·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·I GiambancoR Donato
Dec 1, 1990·Thrombosis Research·J RömischN Heimburger
Feb 22, 1990·European Journal of Biochemistry·C ComéraF Russo-Marie
Dec 1, 1990·Biochemical Society Transactions·M A KaetzelJ R Dedman
Oct 1, 1995·Annals of the Rheumatic Diseases·N J GouldingJ C Edwards
Jun 1, 1995·Baillière's Clinical Haematology·A Redlitz, E F Plow
Aug 1, 1995·Clinical Immunology and Immunopathology·E F MorandS R Holdsworth
Sep 1, 1994·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·E UlvestadR Matre
Nov 1, 1994·Cell and Tissue Research·J S WeinmanS J Weinman
Apr 25, 1994·Neuroscience Letters·N TakeiS Kohsaka
Mar 1, 1994·Trends in Pharmacological Sciences·R J Flower, N J Rothwell
Feb 1, 1993·Current Opinion in Immunology·N J Goulding, P M Guyre
Mar 1, 1993·British Journal of Pharmacology·G CirinoR J Flower
Jan 10, 1996·Experimental Cell Research·S SelbertA A Noegel
Oct 1, 1996·Current Opinion in Neurology·D S Tews, H H Goebel
Oct 11, 1996·Biochimica Et Biophysica Acta·T DuboisF Russo-Marie
Nov 29, 1996·The Journal of Biological Chemistry·B NiliusG Droogmans
Jun 1, 1997·Cellular and Molecular Life Sciences : CMLS·C P Reutelingsperger, W L van Heerde
Nov 14, 1997·American Journal of Reproductive Immunology : AJRI·A AarliR Matre
Feb 28, 1998·The Biochemical Journal·A G Buckland, D C Wilton
Apr 18, 1998·The Biochemical Journal·C Schmitz-PeifferT J Biden
Apr 18, 1998·Molecular and Cellular Biochemistry·S W JansM van Bilsen
Aug 28, 1998·Histochemistry and Cell Biology·R DreierK Riehemann
Feb 15, 2000·Journal of Muscle Research and Cell Motility·C S ClemenA A Noegel
Apr 19, 2002·Molecular Biology and Evolution·Juan-Manuel IglesiasMaria-Pilar Fernandez
Aug 15, 2002·Neuropathology and Applied Neurobiology·S Probst-CousinD Heuss
Mar 28, 2003·Muscle & Nerve·Frank L MastagliaPaul J Zilko

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Citations

Mar 18, 2011·Journal of Neuropathology and Experimental Neurology·Leigh B WaddellSandra T Cooper
Feb 11, 2014·Biochemical and Biophysical Research Communications·Jakob VoelklFlorian Lang
Jun 7, 2014·Pflügers Archiv : European journal of physiology·Dong LuoMichael Föller
Dec 25, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ricardo A ChaurioUdo S Gaipl
Sep 21, 2006·The Journal of Biological Chemistry·Anna K McNeilPaul L McNeil
May 2, 2019·Scientific Reports·Stine Lauritzen SønderJesper Nylandsted
Aug 3, 2019·European Archives of Psychiatry and Clinical Neuroscience·Helena P G JoaquimWagner F Gattaz
Aug 30, 2017·Frontiers in Cellular and Infection Microbiology·Sei-Jung LeeHo Jae Han

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