Annexin III implicated in the microglial response to motor nerve injury

Glia
Hiroyuki KonishiHiroshi Kiyama

Abstract

To identify proteins implicated in peripheral nerve regeneration, we performed two-dimensional polyacrylamide gel electrophoresis and subsequent mass spectrometry analysis using nerve-injured hypoglossal nuclei of rat. We have identified annexin III (ANX III/ANX A3) as an induced protein after rat hypoglossal nerve injury. ANX III is known as a Ca2+-dependent phospholipid-binding protein, but its physiological function is mostly unknown. By in situ hybridization and immunohistochemistry, we demonstrated that ANX III expression was induced specifically in activated (axotomy-stimulated) microglia after nerve injury. ANX III was the most prominent ANX expressed in microglia of the major ANX family members (ANX I-VI). Hybridization signals for other ANX mRNAs (II, IV, V, and VI) were mainly observed in neuronal cells, and no significant hybridization signal for ANX I mRNA was detected in hypoglossal nuclei. In cultured microglia, ATP treatment induced ANX III translocation to the ruffling membrane where F-actin was accumulated. Further in vitro studies revealed that ANX III was not secreted and had F-actin binding activity in a Ca2+-dependent manner. These results suggest that ANX III may be a Ca2+-dependent mediator between phosph...Continue Reading

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Citations

Dec 19, 2009·Molecular & Cellular Proteomics : MCP·Faneng Sun, Valeria Cavalli
Jan 6, 2009·Journal of Neurotrauma·Xiaodong YanShaojun Liu
Sep 14, 2010·Neuroscience Letters·Kevin Wai Yin ChongNam Sang Cheung
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Apr 13, 2019·Journal of Neuroinflammation·Akira SayoHiroshi Kiyama
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Jul 6, 2021·Neural Plasticity·Zengli ZhangWangyuan Zou
Jul 27, 2021·Diabetic Medicine : a Journal of the British Diabetic Association·Erik IsingLars B Dahlin
Mar 14, 2021·Journal of Molecular Neuroscience : MN·Elif Emanetci, Tunahan Çakır

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