PMID: 1459245Dec 14, 1992

Annexin V forms calcium-dependent trimeric units on phospholipid vesicles

FEBS Letters
N O ConchaB A Seaton


The quaternary structure of annexin V, a calcium-dependent phospholipid binding protein, was investigated by chemical cross-linking. Calcium was found to induce the formation of trimers, hexamers, and higher aggregates only when anionic phospholipids were present. Oligomerization occurred under the same conditions annexin-vesicle binding. A model is proposed in which cell stimulation leads to calcium-induced organization of arrays of annexin V lining the inner membrane surface, thus altering properties such as permeability and fluidity.


Jan 26, 2011·European Biophysics Journal : EBJ·Zahia Fezoua-BoubegtitenSophie Lecomte
Jan 1, 1994·The International Journal of Biochemistry·T Cserhåti, M Szögyi
Nov 1, 1996·Neuroscience·T GotowY Uchiyama
Apr 20, 1994·Gene·M P FernándezR O Morgan
Sep 24, 1999·Biochimie·M DanielukJ Bandorowicz-Pikuła
Apr 7, 2011·Nature Communications·Anthony BouterA Brisson
Aug 30, 2002·European Journal of Biochemistry·Lin LiuDavid M Terrian
Dec 1, 1995·Plant Physiology·G B Clark, S J Roux
Nov 1, 1994·European Journal of Biochemistry·J M NeumannA Lewit-Bentley
Sep 15, 1995·European Journal of Biochemistry·B RothhutJ P Oudinet
Sep 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ger van ZandbergenTamás Laskay
Apr 7, 2011·Traffic Injury Prevention·R SolomonB Tinholt
Nov 10, 2005·Autoimmunity·Borut BozicBlaz Rozman
May 6, 2006·FEBS Letters·Marcin BalcerzakS Pikula
Apr 10, 2010·Scandinavian Journal of Clinical and Laboratory Investigation·Lise FalborgMichael Rehling
Apr 30, 2002·Experimental Cell Research·Ariane-Valérie FaureJesus Ayala-Sanmartin
Sep 30, 2008·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·T HuX Yin
Oct 5, 2017·International Journal of Molecular Sciences·Chiara Bianca Maria PlataniaClaudio Bucolo
Dec 20, 2017·Frontiers in Immunology·Nicole D BarthIan Dransfield
Nov 24, 2006·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Jialan ShiGary E Gilbert
Sep 7, 2006·Molecular Human Reproduction·A P Ponnampalam, P A W Rogers
Jan 5, 2008·The Journal of Biological Chemistry·Brian JeppesenJonathan F Tait
Apr 1, 1996·Histochemistry and Cell Biology·M KnochelR D Burgoyne
Dec 1, 2018·Apoptosis : an International Journal on Programmed Cell Death·Kevin KupchoAndrew Niles
Jul 10, 2018·Scientific Reports·Theresa Louise BoyeAdam Cohen Simonsen
Apr 30, 2020·Biomolecules·Peder A G LillebostadPetri Kursula
Aug 26, 1998·The Journal of Biological Chemistry·R LangenW L Hubbell


Dec 1, 1975·Analytical Biochemistry·C E Stauffer
Feb 18, 1992·Biochemistry·D D SchlaepferH T Haigler
Jul 24, 1992·Cell·H C LinR G Anderson
Aug 20, 1992·Journal of Molecular Biology·C RavanatJ M Freyssinet
Jan 20, 1991·Journal of Molecular Biology·G MosserA Brisson
Feb 11, 1991·FEBS Letters·R NewmanM J Crumpton
Mar 19, 1991·Biochemistry·P MeersD Papahadjopoulos
Oct 8, 1991·Biochemistry·W J Zaks, C E Creutz
Mar 5, 1989·Journal of Molecular Biology·R NewmanM J Crumpton
Jun 13, 1966·Biochemical and Biophysical Research Communications·A DuttonS J Singer
Jul 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·G E Davies, G R Stark
Feb 1, 1969·Journal of Cellular Physiology·J P Reeves, R M Dowben
Dec 1, 1983·Biophysical Journal·P MuellerB Rudy
Jul 1, 1980·Biochimica Et Biophysica Acta·R Y Tsien, T J Rink

Related Concepts

Calcium [EPC]
Annexin A5
ANXA5 gene
Protein Conformation
Phospholipid Measurement

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.