PMID: 1459245Dec 14, 1992

Annexin V forms calcium-dependent trimeric units on phospholipid vesicles

FEBS Letters
N O ConchaB A Seaton

Abstract

The quaternary structure of annexin V, a calcium-dependent phospholipid binding protein, was investigated by chemical cross-linking. Calcium was found to induce the formation of trimers, hexamers, and higher aggregates only when anionic phospholipids were present. Oligomerization occurred under the same conditions annexin-vesicle binding. A model is proposed in which cell stimulation leads to calcium-induced organization of arrays of annexin V lining the inner membrane surface, thus altering properties such as permeability and fluidity.

References

Jan 26, 2011·European Biophysics Journal : EBJ·Zahia Fezoua-BoubegtitenSophie Lecomte
Jan 1, 1994·The International Journal of Biochemistry·T Cserhåti, M Szögyi
Nov 1, 1996·Neuroscience·T GotowY Uchiyama
Apr 20, 1994·Gene·M P FernándezR O Morgan
Sep 24, 1999·Biochimie·M DanielukJ Bandorowicz-Pikuła
Apr 7, 2011·Nature Communications·Anthony BouterA Brisson
Aug 30, 2002·European Journal of Biochemistry·Lin LiuDavid M Terrian
Dec 1, 1995·Plant Physiology·G B Clark, S J Roux
Nov 1, 1994·European Journal of Biochemistry·J M NeumannA Lewit-Bentley
Sep 15, 1995·European Journal of Biochemistry·B RothhutJ P Oudinet
Sep 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ger van ZandbergenTamás Laskay
Apr 7, 2011·Traffic Injury Prevention·R SolomonB Tinholt
Nov 10, 2005·Autoimmunity·Borut BozicBlaz Rozman
May 6, 2006·FEBS Letters·Marcin BalcerzakS Pikula
Apr 10, 2010·Scandinavian Journal of Clinical and Laboratory Investigation·Lise FalborgMichael Rehling
Apr 30, 2002·Experimental Cell Research·Ariane-Valérie FaureJesus Ayala-Sanmartin
Sep 30, 2008·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·T HuX Yin
Oct 5, 2017·International Journal of Molecular Sciences·Chiara Bianca Maria PlataniaClaudio Bucolo
Dec 20, 2017·Frontiers in Immunology·Nicole D BarthIan Dransfield
Nov 24, 2006·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Jialan ShiGary E Gilbert
Sep 7, 2006·Molecular Human Reproduction·A P Ponnampalam, P A W Rogers
Jan 5, 2008·The Journal of Biological Chemistry·Brian JeppesenJonathan F Tait
Apr 1, 1996·Histochemistry and Cell Biology·M KnochelR D Burgoyne
Dec 1, 2018·Apoptosis : an International Journal on Programmed Cell Death·Kevin KupchoAndrew Niles
Jul 10, 2018·Scientific Reports·Theresa Louise BoyeAdam Cohen Simonsen
Apr 30, 2020·Biomolecules·Peder A G LillebostadPetri Kursula
Aug 26, 1998·The Journal of Biological Chemistry·R LangenW L Hubbell

Citations

Dec 1, 1975·Analytical Biochemistry·C E Stauffer
Feb 18, 1992·Biochemistry·D D SchlaepferH T Haigler
Jul 24, 1992·Cell·H C LinR G Anderson
Aug 20, 1992·Journal of Molecular Biology·C RavanatJ M Freyssinet
Jan 20, 1991·Journal of Molecular Biology·G MosserA Brisson
Feb 11, 1991·FEBS Letters·R NewmanM J Crumpton
Mar 19, 1991·Biochemistry·P MeersD Papahadjopoulos
Oct 8, 1991·Biochemistry·W J Zaks, C E Creutz
Mar 5, 1989·Journal of Molecular Biology·R NewmanM J Crumpton
Jun 13, 1966·Biochemical and Biophysical Research Communications·A DuttonS J Singer
Jul 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·G E Davies, G R Stark
Feb 1, 1969·Journal of Cellular Physiology·J P Reeves, R M Dowben
Dec 1, 1983·Biophysical Journal·P MuellerB Rudy
Jul 1, 1980·Biochimica Et Biophysica Acta·R Y Tsien, T J Rink

Related Concepts

Calcium [EPC]
Annexin A5
Calcium
ANXA5 gene
Vesicle
Protein Conformation
ANXA1
Phospholipids
Phospholipid Measurement
Annexins

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