Annexin VII: an astroglial protein exhibiting a Ca2+-dependent subcellular distribution

Neuroreport
Christoph S ClemenR Schröder

Abstract

A fundamental issue in neuronal and glial cells is how intracellular rises in Ca2+ are coupled to signaling cascades and changes in subcellular morphology. We studied the expression and localization of annexin VII (synexin), a Ca(2+)-/GTP-dependent membrane fusion protein, in the human CNS. Here, we demonstrate the presence of two annexin VII isoforms (47 and 51 kDa) in human brain tissue as well as its exclusive expression in astroglial cells. An in vitro study of astrocyte-derived C6 rat glioblastoma cells expressing a GFP tagged annexin VII fusion protein demonstrates a sequential redistribution of the fusion protein in response to rising intracellular Ca2+ concentrations. Our findings indicate a role of annexin VII in the regulation of intracellular Ca(2+)-dependent processes in astroglial cells.

References

Nov 3, 1995·The Journal of Biological Chemistry·M B MeyersG I Fishman
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·W S PearD Baltimore
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·H CaohuyH B Pollard
Jun 27, 1997·Biochimica Et Biophysica Acta·V Gerke, S E Moss
May 1, 1997·Somatic Cell and Molecular Genetics·M L Springer, H M Blau
Aug 13, 1998·Glia·A Charles
Jul 31, 1999·The Journal of Biological Chemistry·F CalegariP Rosa
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·M SrivastavaH B Pollard
Feb 15, 2000·Journal of Muscle Research and Cell Motility·C S ClemenA A Noegel

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Citations

Mar 14, 2002·Annals of Neurology·David H GutmannMark A Watson
Dec 4, 2003·Experimental Cell Research·Christoph S ClemenAngelika A Noegel
Oct 7, 2003·International Journal for Parasitology·Malin E-L WeilandStaffan G Svärd
Apr 12, 2005·BMC Neuroscience·Michaela RickChristoph S Clemen
Sep 4, 2007·Biochimica Et Biophysica Acta·Avinash ChanderDevendra G Naidu
Sep 14, 2011·Biochimica Et Biophysica Acta·Tudevdagva GerelsaikhanAvinash Chander

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