Annexins-Coordinators of Cholesterol Homeostasis in Endocytic Pathways

International Journal of Molecular Sciences
Carles RenteroCarlos Enrich

Abstract

The spatiotemporal regulation of calcium (Ca2+) storage in late endosomes (LE) and lysosomes (Lys) is increasingly recognized to influence a variety of membrane trafficking events, including endocytosis, exocytosis, and autophagy. Alterations in Ca2+ homeostasis within the LE/Lys compartment are implicated in human diseases, ranging from lysosomal storage diseases (LSDs) to neurodegeneration and cancer, and they correlate with changes in the membrane binding behaviour of Ca2+-binding proteins. This also includes Annexins (AnxA), which is a family of Ca2+-binding proteins participating in membrane traffic and tethering, microdomain organization, cytoskeleton interactions, Ca2+ signalling, and LE/Lys positioning. Although our knowledge regarding the way Annexins contribute to LE/Lys functions is still incomplete, recruitment of Annexins to LE/Lys is greatly influenced by the availability of Annexin bindings sites, including acidic phospholipids, such as phosphatidylserine (PS) and phosphatidic acid (PA), cholesterol, and phosphatidylinositol (4,5)-bisphosphate (PIP2). Moreover, the cytosolic portion of LE/Lys membrane proteins may also, directly or indirectly, determine the recruitment of Annexins to LE. Strikingly, within LE/Lys...Continue Reading

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Citations

Jan 30, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Y NiuH Wang
Jul 25, 2019·International Journal of Molecular Sciences·Thomas GrewalChrista Buechler
Oct 31, 2019·Cellular and Molecular Life Sciences : CMLS·Elsa Meneses-SalasCarles Rentero
Jun 25, 2020·Cells·Valentina Dallacasagrande, Katherine A Hajjar
Jan 1, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Nicola ChiarelliMarina Colombi
Apr 4, 2021·International Journal of Molecular Sciences·Thomas GrewalUrsula Rescher
Apr 17, 2021·Biochemistry·Martin Berg KlenowAdam Cohen Simonsen
Jul 19, 2021·Clínica e investigación en arteriosclerosis : publicación oficial de la Sociedad Española de Arteriosclerosis·José Martínez-González, Irene Corrales
Jan 25, 2020·Journal of Proteome Research·Kun MengQing-Yu He
Sep 26, 2021·Scientific Reports·Shanmuganathan RajasekaranKrishna Venkateshwaran

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Methods Mentioned

BETA
GTPases
GTPase
nucleotide exchange

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