Annual decline in β-cell function in patients with type 2 diabetes in China.

Diabetes/metabolism Research and Reviews
Zhenxiu GaoQingqing Lou

Abstract

The aim of this study was to investigate the annual decline of β-cell function correlated with disease duration in patients with type 2 diabetes in China. This cross-sectional study included 4792 adults with type 2 diabetes who were recruited from four university hospital diabetes clinics between April 2018 and November 2018. Baseline data were collected from electric medical records. Participants were divided into 21 groups with 1-year diabetes duration interval to assess the decline rate of β-cell function. Homeostatic model assessment model (HOMA 2) model was applied to assess β-cell function. Multiple linear regression model was used to evaluate the association between biochemical and clinical variables and β-cell function. In Chinese patients with type 2 diabetes, β-cell function declined by 2% annually. Using angiotensin receptor blockade (ARB) (β = .048; P = .011), metformin (β = .138; P = .021), or insulin (β = .142; P = .018) was associated with increased β-cell function. However, increased BMI (β = -.215; P = .022), alcohol consumption (β = -.331; P < .001), haemoglobin A1c (β = -.104; P = .027), or increased diabetes duration (β = -.183; P = .003) was significantly and negatively associated with β-cell function. We d...Continue Reading

References

Apr 1, 1988·The Journal of Clinical Investigation·J J ShelmetG Boden
May 27, 2004·Diabetes Care·Tara M WallaceDavid R Matthews
Jan 9, 2007·Trends in Endocrinology and Metabolism : TEM·Paolo Pozzilli, Raffaella Buzzetti
Nov 1, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·M SpoletiniUNKNOWN IMDIAB Group
May 28, 2009·JAMA : the Journal of the American Medical Association·Juliana C N ChanFrank B Hu
Nov 25, 2011·BMC Medical Research Methodology·Anwar BoraiGordon Ferns
Apr 5, 2013·Annals of the New York Academy of Sciences·Ronald C W Ma, Juliana C N Chan
Nov 18, 2016·International Journal of Environmental Research and Public Health·Min-Gyu YooSang Ick Park
Apr 19, 2018·Diabetes/metabolism Research and Reviews·Giuseppina T RussoUNKNOWN BetaDecline Study Group

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