Annual eradication rate of bismuth-containing quadruple therapy as second-line treatment for Helicobacter pylori infection: A 15-year prospective study at a tertiary hospital in Korea

Helicobacter
Kichul YoonDong Ho Lee

Abstract

Bismuth-containing quadruple therapy is widely used as second-line treatment for Helicobacter pylori infection. This prospective study investigated the changes in the annual H. pylori eradication rates of quadruple therapy. This study included an intention-to-treat (ITT) population of 452 subjects who failed first-line eradication therapy for H. pylori between 2003 and 2018. All subjects received a 14-day course of bismuth-containing quadruple therapy consisting of esomeprazole (40 mg twice daily), metronidazole (500 mg thrice daily), bismuth subcitrate (120 mg four times daily), and tetracycline (500 mg four times daily). Per-protocol (PP) analysis of data was performed in subjects who followed up with strict treatment adherence. Eradication was confirmed based on the results of the 13 C-urea breath test, rapid urease test (CLOtest® ), and histopathologic evaluation. Compliance and adverse effects were also investigated. A minimal inhibitory concentration test was performed on tissue samples obtained from 103 subjects. The overall eradication rates following ITT and PP analyses were 78.8% (356/452) and 89.5% (314/351), respectively. The annual eradication success rate did not show significant changes (P = .062 [ITT], P = .857 ...Continue Reading

References

Jul 5, 2007·The American Journal of Gastroenterology·William D CheyUNKNOWN Practice Parameters Committee of the American College of Gastroenterology
Dec 26, 2008·World Journal of Gastroenterology : WJG·Alexander C FordPaul Moayyedi
Dec 18, 2009·Expert Review of Anti-infective Therapy·Lyudmila Boyanova, Ivan Mitov
Mar 23, 2010·Helicobacter·Masahiro AsakaUNKNOWN Japanese Society for Helicobacter Research
Apr 30, 2010·The New England Journal of Medicine·Kenneth E L McColl
Aug 9, 2011·Expert Review of Anti-infective Therapy·Michael SelgradPeter Malfertheiner
Mar 22, 2014·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Ju Yup Lee, Nayoung Kim
Apr 25, 2014·Journal of Gastroenterology and Hepatology·Sang Gyun KimUNKNOWN Korean College of Helicobacter and Upper Gastrointestinal Research
Aug 12, 2014·World Journal of Gastroenterology : WJG·Sinéad M SmithDeirdre McNamara
Sep 1, 2015·Gastroenterology Clinics of North America·David Y Graham, Sun-Young Lee
Jan 11, 2017·The American Journal of Gastroenterology·William D CheySteven F Moss
Jan 7, 2019·The American Journal of Medicine·Robert T KavittIan M Gralnek
Feb 7, 2019·Journal of Gastroenterology and Hepatology·Jung Won LeeDong Ho Lee
Sep 6, 2019·Helicobacter·Anthony O'ConnorColm O'Morain

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Citations

Nov 3, 2020·Expert Opinion on Pharmacotherapy·Sotirios Georgopoulos, Vasilios Papastergiou
Sep 13, 2020·Helicobacter·Anthony O'ConnorColm O'Morain
Jul 10, 2021·World Journal of Gastroenterology : WJG·Xiao-Hua LiHao Chen

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