Annual Research Review: Enduring neurobiological effects of childhood abuse and neglect

Journal of Child Psychology and Psychiatry, and Allied Disciplines
Martin H Teicher, Jacqueline A Samson

Abstract

Childhood maltreatment is the most important preventable cause of psychopathology accounting for about 45% of the population attributable risk for childhood onset psychiatric disorders. A key breakthrough has been the discovery that maltreatment alters trajectories of brain development. This review aims to synthesize neuroimaging findings in children who experienced caregiver neglect as well as from studies in children, adolescents and adults who experienced physical, sexual and emotional abuse. In doing so, we provide preliminary answers to questions regarding the importance of type and timing of exposure, gender differences, reversibility and the relationship between brain changes and psychopathology. We also discuss whether these changes represent adaptive modifications or stress-induced damage. Parental verbal abuse, witnessing domestic violence and sexual abuse appear to specifically target brain regions (auditory, visual and somatosensory cortex) and pathways that process and convey the aversive experience. Maltreatment is associated with reliable morphological alterations in anterior cingulate, dorsal lateral prefrontal and orbitofrontal cortex, corpus callosum and adult hippocampus, and with enhanced amygdala response t...Continue Reading

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Citations

Feb 20, 2016·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Bessel van der Kolk
Apr 10, 2016·Behavioural Brain Research·K Lyons-RuthM H Teicher
May 25, 2016·Proceedings of the National Academy of Sciences of the United States of America·Michael J Meaney
Oct 22, 2016·Neuroscience and Biobehavioral Reviews·Marisa M SilveriJennifer T Sneider
Sep 2, 2016·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Ulrich T EgleManfred Cierpka
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Apr 13, 2017·European Eating Disorders Review : the Journal of the Eating Disorders Association·Janet Treasure, Valentina Cardi
Apr 13, 2017·Development and Psychopathology·Jennifer Blaze, Tania L Roth
Apr 14, 2017·Journal of Child Psychology and Psychiatry, and Allied Disciplines·E B BrownlieJoseph H Beitchman
May 13, 2017·Journal of Evaluation in Clinical Practice·Anna Luise Kirkengen
Jan 18, 2017·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Lisa DinklerHelen Minnis
Jul 18, 2017·Clinical Child Psychology and Psychiatry·Marta CasonatoAlessandra Frigerio
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Dec 1, 2017·Sexual Abuse : a Journal of Research and Treatment·Steffen BarraMarcel Aebi
Oct 9, 2018·Journal of Paediatrics and Child Health·Samantha KaiserGehan Roberts
Jan 3, 2019·Stress : the International Journal on the Biology of Stress·Carina Teixeira RibeiroDiogo Benchimol de Souza
Feb 9, 2019·International Journal of Offender Therapy and Comparative Criminology·Kathleen Green, Kevin Browne

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